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Cilia Biopsy, Histo/Path

Clinical System Name

Surgical Pathology Final Report


Ciliary Biopsies


Electron microscopic analysis of structural integrity of cilia, typically in setting of dyskinesia.

Sample Requirements

Specimen:  Nasal epithelium preferred; nasopharyngeal epithelium accepted; see note below

Container(s):  see below

Preferred Vol:  see below

Minimum Vol:  visible on brush


Note:  Appropriate specimen type is nasal mucosal brushing/biopsy from the inferior nasal.turbinates, or bronchoscopy brushing/biopsy.  Brushings are obtained with a 1 mm x 10 mm bronchoscopy brush.  Sample should be of sufficient volume to be visible on brush.  Cut off the tip of the brush to approximately 5 mm and place directly into a vial containing 10 mL 3% glutaraldehyde obtained from the histology laboratory.  Ensure that the brush or biopsy is immersed in fixative.  Do not invert vial, as brush must remain immersed in fixative.  HAND CARRY TO LAB IMMEDIATELY.

Comment:  Cilia fixative (3% glutaraldehyde) is prepared in Histology Lab (OC.8.901) 987-2580.  Fixative must be picked up from Histology Lab and specimens returned to Histology Lab as soon as possible.  Optimally, the patient should be free of upper respiratory infection and congestion at the time of biopsy.


Processing Instructions

Reject due to:

Spin:  N

Aliquot:  N

Temp: Transport at room termperature;  refrigerate while stored in lab

Note:  Notify Histology immediately when specimen arrives in Lab.  Pathology requisition should accompany sample. Contact on-call pathologist if Histology is unavailable.


Off-site collection:  Specific handling instructions may be obtained from Histology at (206) 987-2580. 


Specimen Type Temperature Time
Tissue Room temp  



STAT Performed TAT
  M-F 8 a.m. - 5 p.m. 1-2 weeks


Performing Laboratory

Seattle Children's Laboratory  


Department:  Histology

Phone Number: (206) 987-2580; for results inquiries call (206) 987-2103.




Method: Electron microscopic examination

Analytical Volume:  n/a

Limitations: Concurrent infection can interfere with interpretation

CPT Codes

CPT codes will vary depending on tests performed.  Call Client Services for more information (206) 987-2617.


Surgical pathology requisition required.