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Aldosterone/Renin Activity Ratio

Clinical System Name

Miscellaneous Test

Synonyms

Plasma Renin Activity
PRA (Plasma Renin Activity)

Aldosterone


 

Sample Requirements

Specimen: Whole Blood

Container(s): Lavender/EDTA

Preferred Vol: 4 mL

Minimum Vol:  2.4 mL

 

Specimen: Whole Blood

Container(s): Red

Preferred Vol: 4 mL

Minimum Vol:  2.4 mL

 

Note: SUPINE: Obtain sample 8-10 AM, fasting starting at midnight, on a normal sodium diet (100-200 mEq/day).

UPRIGHT: Samples obtained before noon (after at least 2 hours in upright position), on a normal sodium diet.

Processing Instructions

Reject due to: Hemolyzed or refrigerated specimens

Spin: Y

Aliquot: Y

Temp: -20 C

Storage location:  CPA freezer, Critical frozen, spun plasma must be frozen within one hour.

 

Off-site collection: Critical frozen, spun plasma must be frozen within one hour.  Spin blood, aliquot plasma and send frozen.  If ordered with other tests, must be received in an individual aliquot container frozen.

Stability

Specimen Type Temperature Time
Plasma Room Temp 6 h
  Refrigerated Unacceptable
  Frozen 1 m
     
Serum Room Temp 8 h
  Refrigerated 5 d
  Frozen 1 m

 

Availability

STAT Performed TAT
N Drawn daily, performed daily 2 - 4 d

 

Performing Laboratory

ARUP Laboratories

Department

Department:  

ARUP Laboratories

500 Chipeta Way
Salt Lake City, UT 84108-1221
 

 

Phone Number

(800) 522-2787

 

Reference Range

 

Age Renin Supine (ng/mL/hr) Upright (ng/mL/hr)
Newborn (1 - 7 days) 2.0 - 35.0 NA
Cord Blood 4.0 - 32.0 NA
1 - 12 months 2.4 - 37.0 NA
13 months - 3 years 1.7 - 11.2 NA
4 - 5 years 1.0 - 6.5 ≤15
6 - 10 years 0.5 - 5.59 ≤17
11 - 15 years 0.5 - 5.9 ≤16
Adult 0.2 - 1.6 0.5 - 4.0

Plasma renin activity measures enzyme ability to convert angiotensinogen to angiotensin I and is limited by the availability of angiotensinogen. Plasma renin activity is not an accurate indicator of enzyme activity when angiotensinogen is decreased.
 

Age Aldosterone Posture Unspecified Supine Upright
0-6 days 5.0-102.0 ng/dL    
1-3 weeks 6.0-179.0 ng/dL    
1-11 months 7.0-99.0 ng/dL    
1-2 years 7.0-93.0 ng/dL    
3-10 years 4.0-44.0 ng/dL    
11-14 years 4.0-31.0 ng/dL    
15 years and older Less than or equal to 31.0 ng/dL Less than or equal to 16.0 ng/dL 4.0-31.0 ng/dL

 

Methodology

Method: Radioimmunoassay/Quantitative Chemiluminescent Immunoassay

Analytical Volume: None specified

Limitations:

CPT Codes

84244, 82088

 

Send Out Instructions

 

Reference Test Name: Aldosterone/Renin Activity Ratio
Reference Test Number:

0070073

Instructions:

Send out Mon - Fri with ARUP courier.