Sign in →

Test Code A STRIATED Striational (Striated Muscle) Antibodies, Serum

Reporting Name

Striational (Striated Muscle) Ab, S

Useful For

As a serological aid in the diagnosis of thymoma, especially in patients with onset of myasthenia gravis (MG) younger than 45 years

 

As a screening test for MG in older patients, especially when tests for muscle acetylcholine receptor (AChR) antibodies are negative

 

Serial measurements are useful in monitoring the efficacy of immunosuppressant treatment in patients with MG

 

Serial measurements are useful after treatment of thymoma

 

Serial measurements in recipients of D-penicillamine or bone marrow allografts may be useful in monitoring autoimmune complications and graft-versus-host disease, respectively

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 1.5 mL


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reference Values

<1:120

Day(s) and Time(s) Performed

Monday through Friday; 4 a.m. and 3 p.m.

Saturday; 6 a.m.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

83520

LOINC Code Information

Test ID Test Order Name Order LOINC Value
STR Striational (Striated Muscle) Ab, S 8097-8

 

Result ID Test Result Name Result LOINC Value
8746 Striational (Striated Muscle) Ab, S 8097-8

Method Description

Protein antigens extracted from adult rat skeletal muscle in 600 mM KCl are applied to wells of an enzyme-linked immunosorbent assay plate. Serially diluted patient's serum is added. After washing, alkaline phosphatase conjugated antibodies to human IgG, IgM, and IgA are added, washing is repeated, and then the enzyme substrate is added. Results are expressed as antibody titer (ie, the greatest dilution at which the optical density of the reaction product is >1.50 x the mean value of 4 normal control sera).(Cikes N, Momoi MY, Williams CL, et al: Striational autoantibodies: quantitative detection by enzyme immunoassay in myasthenia gravis, thymoma, and recipients of D-penicillamine or allogeneic bone marrow. Mayo Clin Proc 1988;63:474-481)

Reject Due To

Hemolysis

Mild OK; Gross reject

Lipemia

Mild OK; Gross reject

Icterus

Mild OK; Gross reject

Other

NA

Testing Algorithm

See Paraneoplastic Evaluation Algorithm in Special Instructions

Method Name

Enzyme Immunoassay (EIA)