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Test Code ADH Arginine Vasopressin, Plasma

Reporting Name

Arginine Vasopressin, P

Useful For

Diagnosis and characterization of diabetes insipidus


Diagnosis of psychogenic water intoxication


As an adjunct in the diagnosis of the syndrome of inappropriate antidiuretic hormone secretion (SIADH), including ectopic arginine vasopressin production

Advisory Information


Specimen Required

Patient Preparation:

1. This test should not be requested on patients who have recently received radioactive material.

2. Have patient fast and thirst for 6 hours (no liquids, including water, are allowed).

Specimen Type: Platelet-poor plasma

Collection Container/Tube: Lavender top (EDTA) iced tube

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL

Collection Instructions: Process 5 mL of EDTA whole blood as follows:

1. Spin down in a refrigerated centrifuge at approximately 1,000 x G (2,000 rpm for a 20-cm radius centrifuge) for 10 minutes.

2. Remove plasma, carefully avoiding the platelet/buffy coat.

Seattle Children's Hospital Note:

Collect 4.0 mL whole blood in iced Lavender top.

Processing: Acceptable to spin in an ambient centrifuge as long as spun down promptly. Aliquot and freeze plasma.

Specimen Type

Plasma EDTA

Specimen Minimum Volume

1.15 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma EDTA Frozen (preferred) 14 days
  Refrigerated  24 hours

Day(s) and Time(s) Performed

Wednesday; 1 p.m.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Method Name

Radioimmunoassay (RIA)

Method Description

Cartridge extraction of acidified plasma is used to prepare the specimen for this Mayo-developed radioimmunoassay (RIA). After acidification, the specimen is centrifuged, applied to a phenyl cartridge, washed, and eluted. The extract is dried under nitrogen, reconstituted with assay buffer and measured for arginine vasopressin by RIA.(Skowsky WR, Rosenbloom AA, Fisher DA: Radioimmunoassay measurement of arginine vasopressin in serum: development and application. J Clin Endocrinol Metab 1974 February;38[2]:278-287)

Reference Values

Adults: <4.3 pg/mL

Reference values were determined on platelet-poor EDTA plasma from individuals fasting no longer than overnight.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
AVP Arginine Vasopressin, P 3126-0


Result ID Test Result Name Result LOINC Value
80344 Arginine Vasopressin, P 3126-0

Reject Due To


Mild OK; Gross reject


Mild OK; Gross OK


Mild OK; Gross OK