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Test Code Amiodarone Level Amiodarone, Serum

Reporting Name

Amiodarone, S

Useful For

Monitoring amiodarone therapy, especially when amiodarone is coadministered with other drugs that may interact


Evaluation of possible amiodarone toxicity


Assessment of patient compliance

Specimen Required

Collection Container/Tube: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 3 mL

Collection Instructions: Draw blood no sooner than 12 hours (trough value) after last dose.

Specimen Type

Serum Red

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Frozen (preferred) 14 days
  Refrigerated  72 hours
  Ambient  24 hours

Day(s) and Time(s) Performed

Tuesday through Saturday; 12 a.m.

Saturday; 4 p.m.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Method Name

High-Turbulence Liquid Chromatography Mass Spectrometry (HTLC-MS/MS)

Method Description

Amiodarone and DEA are diluted in serum with acidic aqueous diluent, containing a deuterated internal standard. Samples are then extracted online by use of turbulent flow technology, and analyzed by liquid chromatography-tandem mass spectrometry (HTLC-MS/MS).(Unpublished Mayo method)

Reference Values


Therapeutic concentration: 0.5-2.0 mcg/mL

Toxic concentration: >2.5 mcg/mL



No therapeutic range established; activity and serum concentration are similar to parent drug.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
AMIO Amiodarone, S 55152-3


Result ID Test Result Name Result LOINC Value
9247 Amiodarone, S 3330-8
2485 Desethylamiodarone 6774-4

Reject Due To


Mild OK; Gross OK


Mild OK; Gross OK


Mild OK; Gross OK


Serum gel tube