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Test Code C1ES C1 Esterase (C1ES) Inhibitor Antigen, Serum

Reporting Name

C1 Esterase Inhibitor Antigen, S

Useful For

Diagnosis of hereditary angioedema


Monitoring levels of C1 esterase inhibitor in response to therapy

Specimen Required

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Fasting preferred but not required.

Specimen Type


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Frozen (preferred) 14 days
  Ambient  72 hours
  Refrigerated  72 hours

Day(s) and Time(s) Performed

Monday through Saturday; Continuously until 3 p.m.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Method Name


Method Description

C1 esterase inhibitor complement antigen (C1ES) is measured by immunonephelometry. Antiserum to C1ES is mixed with patient serum, the light scatter resulting from the antibody interaction with C1ES is measured, and the signal is compared to standard concentrations of C1ES.(Instruction Manual: Siemens Nephelometer II Operations, 2005)

Reference Values

19-37 mg/dL

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
C1ES C1 Esterase Inhibitor Antigen, S 4477-6


Result ID Test Result Name Result LOINC Value
C1ES C1 Esterase Inhibitor Antigen, S 4477-6

Reject Due To


Mild OK; Gross OK


Mild OK; Gross reject


Mild OK; Gross OK