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Test Code CK Creatine Kinase

Clinical System Name

Creatine Kinase

Synonyms

CPK (Creatine Phosphokinase)

Description

Serum CK is almost always increased following acute myocardial infarction or skeletal muscle damage. CK is commonly elevated in myocarditis of any cause, cerebrovascular accidents, rhabdomyolysis, polymyositis, muscular dystrophies (Duchenne’s may have an elevation of 20-200 times normal levels), and acute physical exertion. Low CK may reflect decreased muscle mass, advanced malignancy, or muscle wasting.

Sample Requirements

Specimen: Whole Blood

Container(s): Gold SST, Dark Green/Sodium Heparin, Red, Gold Microtainer, Lt. Green/Li Heparin Microtainer

Preferred Vol: 1 mL

Minimum Vol: 0.1 mL serum or plasma

 

Note:  Method is affected by EDTA, hemolysis and prolonged exposure to RBC's. Not affected by lipemia.

 

Processing Instructions

Reject due to: Age of specimen, hemolysis, incorrect specimen type

Spin: Y

Aliquot: Y

Temp: 2-8oC

Storage Location: Core 5 Chemistry Refrigerator

 

Off-Site Collection: Avoid hemolysis. Spin blood, refrigerate serum or plasma in plastic aliquot container. Method is affected by EDTA, hemolysis and prolonged exposure to RBC's. Not affected by lipemia.

 

Stability

 

Specimen Type Temperature Time
Serum or Plasma RT

4 H

Serum or Plasma 2-8oC

 5 D

Serum or Plasma -20oC or -70oC

30 D

 

Availability

STAT Performed TAT
Y 24/7 1 H

 

Performing Laboratory

Seattle Children's Laboratory    

Department

Department:  Core Chemistry

Phone Number: 206-987-2617

 

 

Reference Range

 

Age IU/L At 37° C
0 - 3 W 0 - 600
3 W- 3 M 0 - 440
> 3 M  (Male) 35 - 230
> 3 M (Female) 20 - 215

 

Methodology

Method:  Multiple Point Rate by Vitros 4600

Analytical Volume:  0.02 mL + 0.03 mL dead space

CPT Codes

82550