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Test Code COPPER Copper, Serum

Reporting Name

Copper, S

Useful For

Diagnosis of:

-Wilson disease

-Primary biliary cirrhosis

-Primary sclerosing cholangitis


Specimen Required


Patient Preparation: High concentrations of gadolinium, iodine, and barium are known to interfere with most metals tests. If gadolinium-, iodine, or barium-containing contrast media has been administered, a specimen should not be collected for 96 hours.

Supplies:

Metal Free B-D Tube (No Additive), 6 mL (T184)

Metal Free Specimen Vial (T173)

Collection Container/Tube: 6-mL Plain, royal blue-top Vacutainer plastic trace element blood collection tube (T184)

Submission Container/Tube: 7-mL Mayo metal-free, screw-capped, polypropylene vial (T173)

Specimen Volume: 0.8 mL

Collection Instructions:

1. Allow the specimen to clot for 30 minutes; then centrifuge the specimen to separate serum from the cellular fraction.

2. Remove the stopper. Carefully pour specimen into Mayo metal-free, polypropylene vial, avoiding transfer of the cellular components of blood. Do not insert a pipet into the serum to accomplish transfer, and do not ream the specimen with a wooden stick to assist with serum transfer.

3. See Trace Metals Analysis Specimen Collection and Transport in Special Instructions for complete instructions.


Seattle Children's Hospital Note:

Collect 1.6 mL whole blood in Royal Blue Top trace element tube.

 

Processing Note: Use of a standard pipette is acceptable for aliquoting these samples.

Specimen Type

Serum

Specimen Minimum Volume

0.2 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Day(s) and Time(s) Performed

Monday; 2 p.m.

Tuesday through Friday; 5 p.m.

Saturday; 2 p.m.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Method Name

Dynamic Reaction Cell-Inductively Coupled Plasma-Mass Spectrometry (DRC-ICP-MS)

Method Description

Copper in serum is analyzed by inductively coupled plasma-mass spectrometry in dynamic reaction cell mode using cobalt, gallium, yttrium, and rhodium as summed internal standards and a salt matrix calibration.(Unpublished Mayo method)

Reference Values

0-2 months: 0.40-1.40 mcg/mL   

3-6 months: 0.40-1.60 mcg/mL

7-9 months: 0.40-1.70 mcg/mL

10-12 months: 0.80-1.70 mcg/mL

13 months-10 years: 0.80-1.80 mcg/mL

≥11 years: 0.75-1.45 mcg/mL

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

82525

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CUS Copper, S 5631-7

 

Result ID Test Result Name Result LOINC Value
8612 Copper, S 5631-7

Reject Due To

Hemolysis

Mild OK; Gross OK

Lipemia

Mild OK; Gross OK

Icterus

Mild OK; Gross reject

Other

NA

Forms

If not ordering electronically, complete, print, and send a General Request Form (T239) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/general-request-form.pdf)