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Test Code CSF IgG/Alb IgG/Albumin Ratio, Spinal Fluid

Reporting Name

IgG/Albumin Ratio, CSF

Useful For

The cerebrospinal fluid (CSF) index is useful in the diagnosis of individuals with multiple sclerosis. In the absence of a paired CSF and serum specimen, the CSF IgG/albumin ratio can be assessed.


The index is independent of the activity of the demyelinating process.

Specimen Required

Collection Container/Tube: Sterile vial

Collection Container/Tube: Plastic vial

Specimen Volume: 1 mL

Specimen Type


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
CSF Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days

Day(s) and Time(s) Performed

Monday through Saturday; 2 p.m.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Method Name


Method Description

Nephelometry (Siemens Nephelometer II Operators Manual 1999)

Reference Values

CSF IgG: 0.0-8.1 mg/dL

CSF albumin: 0.0-27.0 mg/dL

CSF IgG/albumin: 0.00-0.21

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information



LOINC Code Information

Test ID Test Order Name Order LOINC Value
CASF IgG/Albumin Ratio, CSF 2470-3


Result ID Test Result Name Result LOINC Value
IGG_C IgG, CSF 2464-6
ALB_C Albumin, CSF 1746-7
AIGAC IgG/Albumin, CSF 2470-3

Reject Due To


Mild OK; Gross OK


Mild OK; Gross OK


Mild OK; Gross OK