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Test Code DCM PnlUM DCM/LVNC Sequencing Panel

Important Note


This panel has been discontinued by GeneDx Lab and replaced with a 61 gene

DCM/LVNC Sequencing and Deletion/Duplication Panel (Test code J554 at


This panel includes 38 genes associated with dilated cardiomyopathy.

Clinical System Name

DCM/LVNC Sequencing Panel


Nonsyndromic dilated cardiomyopathy (DCM) is characterized by left ventricular enlargement and systolic dysfunction, a reduction in the myocardial force of contraction. DCM usually presents with any one of the following:

  • Heart failure with symptoms of congestion (edema, orthopnea, paroxysmal dyspnea) and/or reduced cardiac output (fatigue, dyspnea on exertion)
  • Arrhythmias and/or conduction system disease
  • Thromboembolic disease (from left ventricular mural thrombus) including stroke

Sample Requirements

Specimen: Whole Blood

Container(s): Lavender/EDTA

Preferred Vol: 5 mL

Minimum Vol: 2 mL


Note: GeneDX does not require consent forms to be completed. Oral rinse (30-40 mL) are also accepted.


Processing Instructions

Reject due to:

Spin: N

Aliquot: N

Temp: 2 - 4 C

Storage location: Refrigerate in CPA refrigerator Sendouts rack. Samples drawn on a Friday can be refrigerated until Monday shipment. Samples drawn on a Friday before a Monday holiday must have DNA extraction.


Off-site collection: Send whole blood refrigerated.


Specimen Type Temperature Time
Whole Blood Room temp 7 d
  Refrigerated 7 d
  Frozen N



STAT Performed TAT
N   10 w


Performing Laboratory




207 Perry Parkway
Gaithersburg, MD 20877
(301) 519-2100

Reference Range

Interpretive report is provided


Method: Next-gen Sequencing

Analytical Volume: 2 mL


Special Instructions

Links to:




Test information sheet

Clinical Utility

This panel can provide confirmation of a clinical diagnosis in symptomatic patients and differentiation of hereditary DCM from acquired (non-genetic) causes of DCM/LVNC. GeneDx estimates that this panel will identify a disease-causing mutation in 40% of patients with familial DCM. If a pathogenic mutation is identified a targeted test can be offered to at-risk family members.


GeneReviews: Dilated Cardiomyopathy Overview

Send Out Instructions


Reference Test Name:

DCM/LVNC Sequencing Panel

Reference Test Number: 635
Instructions: GeneDx accepts Saturday delivery. Whole blood specimens may be stored refrigerated for up to 7 days prior to shipping. Ship overnight via FedEx M - F, ambient temperature.