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Test Code DGP IgG Gliadin (Deamidated) Ab, IgG

Important Note

DGP IgG replaced DGP IgA+IgG Screen, effective January 8, 2018. 

Clinical System Name

Gliadin (Deamidated) Ab, IgG

Synonyms

DAGL

Gliad Ab

DGP

DGP IgG

Description

 

This test is used in the diagnosis and monitoring of patients with Celiac Disease.  It measures the IgG isotypes of the gliadin protein after it has been selectively deamidated by tissue transglutaminase.  Studies have shown that the sensitivity and specificity of DGP, IgA and IgG for celiac disease are comparable to tissue transglutaminase, and higher than that of endomysial antibodies (EMA). In addition to tTG-IgA, DGP is recommended in place of EMA for IgA deficient patients (2% of our population), for patients in whom a second test is desired based on clinical history, and in patients less than two years of age.

 

 

Sample Requirements

Specimen: Whole blood

Container(s): Gold SST Microtainer, Red

Preferred Vol: 1 mL

Minimum Vol: 0.5 mL

 

Note:

 

Processing Instructions

Reject due to:

Spin: Y

Aliquot: Y

Temp: 2-8 C

Storage location: Transfer to plastic aliquot container affixed with larger Cerner label. Refrigerate in CPA, FrigF rack.

Off-site collection: Spin blood, transfer serum to plastic aliquot container. Refrigerate specimen.

Stability

Specimen Type Temperature Time
separated serum  Room temp  
  Refrigerated 7 d
  Frozen 8 m

 

Availability

STAT Performed TAT
N M-F 1-3 d

 

Performing Laboratory

Seattle Children's Laboratory    

 

Department

Department:  Chemistry

Location: Chem East

Phone Number: (206) 987-3694

 

 

 

Reference Range

 

  Units/mL
Negative < 15
Positive > 15

 

Methodology

Method: Immunoassay on Bioplex 2200

Analytical Volume: 100 mcL serum

Limitations:

CPT Codes

83516