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Test Code DHPR Act Dihydropteridine Reductase Activity

Important Note

This testing replaces PKU Cofactor Variant Screening at Perkin Elmer.

Additional Codes


Dihydropteridine Reductase Activity

Clinical System Name

Dihydropteridine Reductase Activity


Dihydropteridine Reductase, Bld

PKU Cofactor

Sample Requirements

Specimen: Whole Blood

Container(s): Dried Blood Spot Card

Preferred Vol:See Comments

Minimum Vol: 2 - 4 full circles of blood


Note: Air dry filter paper samples in the dark. Place patient label on PKU card (do not need to fill out State Newborn Screen information such as birthweight or mother's name). Place in a paper envelope (no plastic bags)!

Processing Instructions

Reject due to: NA, forward to Send Outs

Spin: N

Aliquot: N

Temp: RT

Storage location: Allow Blood Spots to air dry in the dark. Place dried Blood Spots and labels in the room temp Send Outs rack.


Specimen Type Temperature Time
  Room temp  



STAT Performed TAT
N M - F 0800-1700 12-15 d


Performing Laboratory

University of Illinois Medical Center

Biochemical Genetics

820 S. Wood, Rm 337 Bldg 911 CSN

Chicago, IL 60612


Phone Number: (312) 996-5326



Department: Send Outs

Phone Number: (206) 987-2563


Reference Range

Dihydropteridine Reductase, Filter Paper, Blood 1.133 ± 0.345 umol/minute/disc



Dihydropteridine Reductase, Filter Paper, Blood

Method: Enzyme assay




CPT Codes


Send Out Instructions


Reference Test Name:

Dihydropteridine Reductase Activity

Reference Test Number:  
Instructions: Ship Monday - Thursday to University of Illinois via FedEx. Saturday delivery is not acceptable.