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Test Code EculizPhrm Eculizumab Pharmacokinetic Assay

Clinical System Name

Eculizumab Pharmacokinetic Assay

Synonyms

Eculizumab Level + CH50 Cincinnati Panel

Sample Requirements

Specimen: Whole blood

Container(s):  Red

Preferred Vol: 4 mL

Minimum Vol:  2 mL

 

Note: Draw blood between 6 - 10 am. Deliver to the Lab within 1/2  hour of collection.

Processing Instructions

Reject due to: SST, Freeze thaw > 2 cycles, Refrigerated

 

Spin: Y

Aliquot: Y

Temp:-20 C

Storage location: Separate serum from cells within 2 hours of collection. Place sample in the CPA freezer send-outs rack.

 

Off-site collection:  Separate serum from cells within 2 hours of collection and freeze.

Stability

Specimen Type Temperature Time
Serum Room temp

N

  Refrigerated N
  Frozen

> 1 y

 

Availability

STAT Performed TAT
N Drawn daily, performed biweekly 7 - 14 d

 

Performing Laboratory

Cincinnati Children’s Hospital Medical Center

Department

Department:  

Cincinnati Children’s Hospital Medical Center

3333 Burnet Avenue

Lab Processing B-4

Cincinnati Ohio 45229

 

Phone Number

(513) 636-7355

 

Reference Range

Eculizumab Level >500 mcg/mL
CH50 CCH 101-300 CH50 Units

 

Eculizumab is considered to be present in a therapeutic level in aHUS if the trough serum concentration is >99 μg/mL, and in PNH if the serum concentration is >35 μg/mL.

 

 

Methodology

Method: ELISA

Analytical Volume: None specified

Limitations:

CPT Codes

80299, 86162

Send Out Instructions

 

Reference Test Name: Eculizumab Pharmakokinetic Assay
Reference Test Number: Eculizumab Pharmakokinetic Assay
Instructions: Ship frozen on dry ice overnight via FedEx to Cincinnati Children's Hospital.