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Test Code Fluoxetine Fluoxetine, Serum

Reporting Name

Fluoxetine, S

Useful For

Monitoring serum concentration of fluoxetine during therapy


Evaluating potential toxicity


Evaluating patient compliance

Specimen Required

Container/Tube: Red top

Specimen Volume: 1 mL

Collection Instructions: Spin down and separate serum from cells within 2 hours of draw.

Specimen Type

Serum Red

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 14 days
  Frozen  14 days
  Ambient  24 hours

Day(s) and Time(s) Performed

Wednesday; 12 a.m.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Method Name

High-Turbulence Liquid Chromatography Mass Spectrometry (HTLC-MS/MS)

Method Description

Serum samples containing fluoxetine and norfluoxetine are diluted in an aqueous solution containing deuterated internal standards, then injected onto a high turbulence liquid chromatography system for online extraction. Detection is by tandem mass spectrometry.(Unpublished Mayo method)

Reference Values

Fluoxetine + norfluoxetine: 120-300 ng/mL

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
FLUOX Fluoxetine, S In Process


Result ID Test Result Name Result LOINC Value
80228 Fluoxetine, S 3644-2
251 Norfluoxetine, S 3868-7
252 Fluoxetine+Norfluoxetine 10339-0

Reject Due To


Mild OK; Gross OK


Mild OK; Gross OK


Mild OK; Gross OK


Serum gel tube