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Test Code Hb Denat Unstable Hemoglobin, Blood

Reporting Name

Unstable Hemoglobin, B

Useful For

Work-up of congenital hemolytic anemias


Specimen Required


Only orderable as part of a profile or as a reflex. For more information see HAEVP / Hemolytic Anemia Evaluation; or HBELC / Hemoglobin Electrophoresis Cascade, Blood; or THEVP / Thalassemia and Hemoglobinopathy Evaluation; or REVE / Erthrocytosis Evaluation; or MEVP / Methemoglobinemia Evaluation.


Specimen Type

Whole Blood EDTA

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Whole Blood EDTA Refrigerated 7 days

Performing Laboratory

Mayo Medical Laboratories in Rochester

Method Name

Only orderable as part of a profile or as a reflex. For more information see HAEVP / Hemolytic Anemia Evaluation; or HBELC / Hemoglobin Electrophoresis Cascade, Blood; or THEVP / Thalassemia and Hemoglobinopathy Evaluation; or REVE / Erthrocytosis Evaluation; or MEVP / Methemoglobinemia Evaluation.

Method Description

Unstable hemoglobins precipitate in dilute solutions of isopropanol. Washed erythrocytes are hemolyzed and cleared by centrifugation. Isopropanol is added. The hemolysate is incubated at 37° C for 20 minutes and examined for turbidity. There is no turbidity with normal hemoglobins.(Schmidt RM: Laboratory diagnosis of hemoglobinopathies. In Hematology Clinical and Laboratory Practice. Edited by RL Bick. St. Louis, Mosby-Year Book Inc, 1993, pp 327-389)

Reference Values

Only orderable as part of a profile or as a reflex. For more information see HAEVP / Hemolytic Anemia Evaluation; or HBELC / Hemoglobin Electrophoresis Cascade, Blood; or THEVP / Thalassemia and Hemoglobinopathy Evaluation; or REVE / Erthrocytosis Evaluation; or MEVP / Methemoglobinemia Evaluation.

 

Normal (reported as normal [stable] or abnormal [unstable])

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

83068

LOINC Code Information

Test ID Test Order Name Order LOINC Value
UNHB Unstable Hemoglobin, B In Process

 

Result ID Test Result Name Result LOINC Value
9095 Hemoglobin, Unstable, B 4639-1