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Test Code IGA SUB GR IgA Subclasses, Serum

Reporting Name

IgA Subclasses, S

Useful For

Investigation of immune deficiency due to IgA2 deficiency

 

Evaluating patients with anaphylactic transfusion reactions

 


Specimen Required


Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 1 mL


Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 7 days
  Ambient  7 days
  Frozen  7 days

Day(s) and Time(s) Performed

Monday through Saturday; Continuously

Performing Laboratory

Mayo Medical Laboratories in Rochester

Method Name

Nephelometry for Total IgA, IgA1, and IgA2

Method Description

The assay is performed on a Siemens NII nephelometer. Nephelometry is based on the increase in light scatter that occurs when antibody binds to antigen. The increase in light scatter is proportional to the amount of antigen present in the sample. The assay uses immune reagent sets from The Binding Site.(Package insert: Human IgA Subclass Liquid Latex Reagent Kits. The Binding Site)

Reference Values

IgA

0-<5 months: 7-37 mg/dL

5-<9 months: 16-50 mg/dL

9-<15 months: 27-66 mg/dL

15-<24 months: 36-79 mg/dL

2-<4 years: 27-246 mg/dL

4-<7 years: 29-256 mg/dL

7-<10 years: 34-274 mg/dL

10-<13 years: 42-295 mg/dL

13-<16 years: 52-319 mg/dL

16-<18 years: 60-337 mg/dL

≥18 years: 61-356 mg/dL

 

IgA1

0-<5 months: 10-34 mg/dL

5-<9 months: 14-41 mg/dL

9-<15 months: 20-50 mg/dL

15-<24 months: 24-58 mg/dL

2-<4 years: 16-162 mg/dL

4-<7 years: 17-187 mg/dL

7-<10 years: 21-221 mg/dL

10-<13 years: 27-250 mg/dL

13-<16 years: 36-275 mg/dL

16-<18 years: 44-289 mg/dL

≥18 years: 50-314 mg/dL

 

IgA2

0-<5 months: 0.4-5.5 mg/dL

5-<9 months: 1.5-6.2 mg/dL

9-<15 months: 2.8-7.0 mg/dL

15-<24 months: 3.9-7.7 mg/dL

2-<4 years: 1.3-31.1 mg/dL

4-<7 years: 1.1-39.1 mg/dL

7-<10 years: 1.4-48.0 mg/dL

10-<13 years: 2.6-53.4 mg/dL

13-<16 years:  4.7-55.1 mg/dL

16-<18 years: 6.6-54.3 mg/dL

≥18 years: 9.7-156.0 mg/dL

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82784-IgA

82787 x 2-Immunoglobin subclasses

LOINC Code Information

Result ID Test Result Name Result LOINC Value
IGA_ IgA 2458-8
IGA1_ IgA1 6886-6
IGA2_ IgA2 6939-3

Reject Due To

Hemolysis

Mild OK; Gross OK

Lipemia

Mild OK; Gross reject

Icterus

Mild OK; Gross OK

Other

NA