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Test Code INHIBIN B Inhibin B, Serum

Reporting Name

Inhibin B, S

Useful For

As an aid in the diagnosis of granulosa cell tumors and mucinous epithelial ovarian tumors

 

Monitoring of patients with granulosa cell tumors and epithelial mucinous-type tumors of the ovary known to overexpress inhibin B

 

As an adjunct to follicle-stimulating hormone testing during infertility evaluation


Specimen Required


Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 0.4 mL


Seattle Children's Hospital Note:

Collect 0.8 mL whole blood in a Red top.

Specimen Type

Serum

Specimen Minimum Volume

0.2 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 7 days
  Frozen  90 days

Day(s) and Time(s) Performed

Monday, Wednesday, Friday; 9:00 a.m.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Method Description

Inhibin B Gen II ELISA (enzyme-linked immunosorbent assay) is an enzymatically amplified 3-step "sandwich'' assay. Sample is incubated in wells that have been coated with antiactivin B antibody. After incubation and washing, the wells are incubated with biotinylated anti-inhibin detection antibody. After a second incubation and washing step, the wells are incubated with streptavidin labeled with the enzyme horseradish peroxidase. Antibody-analyte complex is detected by dual wavelength absorbance measurement after addition of the tetramethylbenzidine substrate. The absorbance measured is directly proportional to the concentration of inhibin B in the samples.(Package insert: Inhibin B Gen II ELISA kit, Beckman Coulter, Inc. Brea, CA)

Reference Values

Males

0-23 months: <430 pg/mL

2-4 years: <269 pg/mL

5-7 years: <184 pg/mL

8-10 years: <214 pg/mL

11-13 years: <276 pg/mL

14-17 years: <273 pg/mL

Adults: <399 pg/mL

Females

0-23 months: <111 pg/mL

2-4 years: <44 pg/mL

5-7 years: <27 pg/mL

8-10 years: <67 pg/mL

11-13 years: <120 pg/mL

14-17 years: <136 pg/mL

Premenopausal

Follicular: <139 pg/mL

Luteal: <92 pg/mL

Postmenopausal: <10 pg/mL

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

83520

LOINC Code Information

Test ID Test Order Name Order LOINC Value
INHB Inhibin B, S 56940-0

 

Result ID Test Result Name Result LOINC Value
88722 Inhibin B, S 56940-0

Reject Due To

Hemolysis

Mild OK; Gross reject

Lipemia

Mild OK; Gross OK

Icterus

NA

Other

NA