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Test Code Itraconaz Itraconazole, Serum

Reporting Name

Itraconazole, S

Useful For

Verifying systemic absorption of orally administered itraconazole

 

The test is indicated in patients with life-threatening fungal infections and in patients considered at risk for poor absorption or rapid clearance of itraconazole.


Specimen Required


Collection Container/Tube: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL


Specimen Type

Serum Red

Specimen Minimum Volume

0.18 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 29 days
  Ambient  29 days
  Frozen  29 days

Day(s) and Time(s) Performed

Tuesday through Saturday; 8 a.m.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Method Description

Itraconazole and hydroxyitraconazole are extracted by mixing serum samples with acetonitrile to precipitate proteins. The supernatant is removed, and analyzed by an in-house developed liquid chromatography-tandem mass spectrometry (LC-MS/MS) method.(Unpublished Mayo method)

Reference Values

ITRACONAZOLE (TROUGH)

>0.5 mcg/mL (localized infection)

>1 mcg/mL (systemic infection)

 

HYDROXYITRACONAZOLE

No therapeutic range established; activity and serum concentration are similar to parent drug.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

80299

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ITCON Itraconazole, S 10989-2

 

Result ID Test Result Name Result LOINC Value
81247 Itraconazole, S 10989-2
5122 Hydroxyitraconazole No LOINC Needed

Reject Due To

Hemolysis

Mild OK; Gross OK

Lipemia

Mild OK; Gross OK

Icterus

Mild OK; Gross OK

Other

Serum gel tube