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Test Code Lysozyme Lysozyme (Muramidase), Plasma

Important Note


Due to stability requirement this test  is: 1) limited to Children's locations only, 2) cannot be added-on, and 3) must be frozen within 2 hours of collection.

Reporting Name

Lysozyme (Muramidase), P

Useful For

Confirming marked increases in the granulocyte or monocyte pools as in granulocytic or monocytic leukemias, myeloproliferative disorders, and malignant histiocytosis


Following the course of therapy in cases of chronic granulocytic or chronic monocytic leukemias

Specimen Required

Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL

Seattle Children's Hospital Note:

Collect 4.0 mL whole blood in a Lavender top.

Specimen Type

Plasma EDTA

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma EDTA Frozen 30 days

Day(s) and Time(s) Performed

Monday through Friday

Performing Laboratory

Mayo Medical Laboratories in Rochester

Method Name


Method Description

The term "lysozyme" is derived from the ability of this enzyme to dissolve the walls of certain bacteria, including Micrococcus lysodeikticus. This organism is suspended in buffer, and the plasma sample is added. The resulting decrease in turbidity is measured spectrophotometrically. The rate of clearing is a reflection of the concentration of the enzyme.(Litwack G: Photometric determination of lysozyme activity. Proc Soc Exp Biol Med 1955;89:401-403)

Reference Values

≥12 months: 2.7-9.4 mcg/mL

Reference values have not been established for patients who are <12 months of age.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
MUR Lysozyme (Muramidase), P 2589-0


Result ID Test Result Name Result LOINC Value
MUR Lysozyme (Muramidase), P 2589-0

Reject Due To


Mild OK; Gross OK


Mild OK; Gross OK