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Test Code SELENIUM Selenium, Serum

Reporting Name

Selenium, S

Useful For

Monitoring selenium replacement therapy


Specimen Required


Collection Container/Tube: 6-mL Plain, royal blue-top Vacutainer plastic trace element blood collection tube (T184)

Submission Container/Tube: 7-mL Mayo metal-free, screw-capped, polypropylene vial (T173)

Specimen Volume: 0.8 mL

Collection Instructions:

1. Allow the specimen to clot for 30 minutes; then centrifuge the specimen to separate serum from the cellular fraction.

2. Remove the stopper. Carefully pour specimen into a Mayo metal-free, polypropylene vial, avoid transferring the cellular components of blood. Do not insert a pipette into the serum to accomplish transfer, and do not ream the specimen with a wooden stick to assist with serum transfer.

3. See Trace Metals Analysis Specimen Collection and Transport in Special Instructions for complete instructions.

Additional Information: 

1. High concentrations of gadolinium, iodine, and barium are known to interfere with most metals tests. If either gadolinium-, iodine-, or barium-containing contrast media has been administered, a specimen should not be collected for 96 hours.

2. If ordering the trace element blood collection tube from BD, order catalog #368380.


Seattle Children's Hospital Note:

Collect 1.6 mL whole blood in Navy Blue Top trace element tube. (Lawson #11930).

 

Processing Note: Use of a standard pipette is acceptable for aliquoting these samples.

Specimen Type

Serum

Specimen Minimum Volume

0.2 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days

Day(s) and Time(s) Performed

Monday; 2 p.m.; Tuesday through Friday; 5 p.m.; Saturday; 2 p.m.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Method Name

Dynamic Reaction Cell-Inductively Coupled Plasma-Mass Spectrometry (DRC-ICP-MS)

Method Description

Selenium, copper and zinc in serum are analyzed by inductively coupled plasma-mass spectrometry in dynamic reaction cell mode using cobalt, gallium, yttrium, and rhodium as summed internal standards and a salt matrix calibration. (Hanley MM, Murray DL, Moyer TP, et al: Selenium, copper and zinc serum: Attenuation of Interferences by Collision/Reaction Cell ICP-MS [Abstract WP22]. Winter Conference on Plasma Spectrochemistry, Tucson, Arizona, January 9-14, 2012)

Reference Values

0-2 months: 45-90 ng/mL

3-6 months: 50-120 ng/mL

7-9 months: 60-120 ng/mL

10-12 months: 70-130 ng/mL

>1 year: 70-150 ng/mL

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

84255

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SES Selenium, S 5724-0

 

Result ID Test Result Name Result LOINC Value
9765 Selenium, S 5724-0

Reject Due To

Hemolysis

Mild OK; Gross OK

Lipemia

Mild OK; Gross OK

Icterus

Mild OK; Gross reject

Other

NA