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Test Code Tetrabiop Tetrahydrobiopterin + Neopterin, CSF

Important Note

Specimens collected for this test may also be used for CSF Neurotransmitter Metabolites and/or CSF 5-Methyltetrahydrofolate - all performed at the same reference laboratory. Separate CSF specimens should be submitted for all other testing.

Clinical System Name

Tetrahydrobiopterin + Neopterin, CSF

Synonyms

BH4 & Neopterin Profile, CSF
Neopterin & Tetrahydrobiopterin Profile, CSF

Sample Requirements

Specimen: Cerebral Spinal Fluid

Container(s): See Comments

Preferred Vol: 4.5 mL

Minimum Vol: 1.5 mL split between tubes #1 - #3 (0.5 mL each, run risk of not being able to add other testing)

 

Note: Call the Laboratory for appropriate specimen collection containers. Each set consists of 5 numbered micro-centrifuge tubes. One complete set of tubes is required per patient. Fill each tube to the marked line. Place the tubes on ice at the bedside immediately after collection. Hand deliver specimens to the Lab immediately.

Processing Instructions

Reject due to:

Spin:

Aliquot:

Temp: - 70 C

Storage location: LAB ASSISTANTS: give specimens to send outs department immediately. IF SEND OUTS NOT AVAILABLE: If the sample is blood contaminated, the tubes should immediately be centrifuged and the clear CSF transferred to new similarly labeled tubes. Freeze all 5 specimen tubes together in the -70 freezer send outs rack ASAP after collection.

 

Off-site collection:

Stability

Specimen Type Temperature Time
CSF Room temp N
  Refrigerated N
  Frozen Y

 

Availability

STAT Performed TAT
  Collect M - F 0800-1630  2 - 3 w

 

Performing Laboratory

Medical Neurogenetics

Department

Department:  

Medical Neurogenetics

5424 Glenridge Dr
Atlanta, GA 30342
 

Phone Number: (678) 225-0222 ext 201

 

 

 

 

Reference Range

 

 

AGE (years) NEOPTERIN nmol/L Tetrahydrobiopterin (BH4) nmol/L
0 - 0.2 7-65 40-105
0.2 - 0.5 7-65 23-98
0.5 - 2.0 7-65 18-58
2.0 - 5.0 7-65 18-50
5.0 - 10 7-40 9-40
10 - 15 8-33 9-32
Adults 8-28 10-30

Interpretation provided by reference laboratory

Methodology

Method: None specified

Analytical Volume: 1.5 mL

Limitations:

CPT Codes

82542 (TLZ 04/18/16)

Send Out Instructions

 

Reference Test Name: Tetrahydrobiopterin & Neopterin Profile
Reference Test Number: NC03
Instructions: If the sample is blood contaminated, the tubes should immediately be centrifuged and the clear CSF transferred to new similarly labeled tubes. Freeze all 5 specimen tubes together in the -70 freezer send outs rack ASAP after collection. Ship on dry ice.