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Test Code VORICONZ Voriconazole Level

Clinical System Name

Voriconazole Level

Synonyms

Antifungal drug

Sample Requirements

Specimen: Whole blood

Container(s): Red

Preferred Vol:1 mL

Minimum Vol: 1 mL

 

Note: Please allow a minimum of 72 h after starting or changing a dose before drawing a Voriconazole level. Draw trough level 30-60 min before next dose. Microtainers are unacceptable.

 

Processing Instructions

Reject due to: Serum separator tubes

Spin: Y

Aliquot:Y

Temp: - 20 C

Storage location: Freeze 0.4 mL serum in CPA Freezer, Fz5 rack.

 

Off-site collection: Transfer 0.4 mL serum in plastic tube and store and send frozen.

Stability

Specimen Type Temperature Time
  Room temp 1 d
  Refrigerated 1 w
  Frozen 6 m

 

Availability

STAT Performed TAT
N M-F Same day if received by 10:00; 1-3 d

 

Performing Laboratory

Seattle Children's Laboratory    

 

Department

Department:  Chemistry

Location: Chem West

Phone Number: (206) 987-2617

Reference Range

Trough therapuetic range 1 - 5.5 mcg/mL

 

Trough level (ie, immediately before next dose) monitoring is recommended. Trough levels >6 mcg/mL (and especially >10 mcg/mL) have been associated with toxicity in several reports. Trough levels <1 mcg/mL have been associated with suboptimal response in several reports. 

Methodology

Method: LC/MS/MS

Analytical Volume: 0.15 mL serum

Limitations:

CPT Codes

80299

Critical Values

> 10.0 mcg/mL