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Test Code Vasc Pnl Vascular Aneurysm Panel

Important Note

This panel includes sequencing for 23 genes: ACTA2, BGN, CBS, COL3A1, FBN1, FBN2, FOXE3, LOX, MAT2A, MFAP5, MYH11, MYLK, PLOD3, PRKG1, SKI, SLC2A10, SMAD2, SMAD3, SMAD4, TGFB2, TGFB3, TGFBR1, and TGFBR2.

Clinical System Name

Vascular Aneurysm Genomic Panel

Synonyms

Core Familial Aneurysm Panel

VscAnP

Vascular Aneurysm Genomic Panel

Arterial Aneurysm

 

Sample Requirements

Specimen: Whole blood

Container(s): Lavender/EDTA

Preferred Vol: 7 mL

Minimum Vol:  3mL

 

Specimen: DNA

Container(s): Sterile plastic tube

Preferred Vol: 5 µg DNA at a minimum concentration of ≥200 ng/µl

Minimum Vol:

Note:

Processing Instructions

Reject due to:

Spin: N

Aliquot: N

Temp: RT

Storage location:  Do not spin. Whole blood may be stored at 4°C until shipped and is stable for 3-5 days in the refrigerator.

 

Off-site collection: Do not spin. Keep whole blood at room temperature

Stability

Specimen Type Temperature Time
Whole Blood Room temp

3 d

Whole Blood Refrigerated 7 d
Whole Blood Frozen

N

Extracted DNA Room temp 3-4 d
Extracted DNA Refrigerated 1 y
Extracted DNA Frozen Indefinitely

 

Availability

STAT Performed TAT
N Drawn daily 5 - 7 w

 

Performing Laboratory

University of Washington

Dept of Laboratory Medicine
Collagen Diagnostics Laboratory

Department

Department:  

Collagen Diagnostic Laboratory

Room H-561 Health Science Bldg.
1959 NE Pacific Street, University of Washington
Seattle, WA 98195-7655

 

Phone: (206) 543-0459

Genetic Counselors: 206-543-5464


 

Phone Number

(206) 685-6066

 

Methodology

Method: Next Generation Sequencing:  Next generation DNA sequencing is performed to identify nucleotide variants in the coding portion of the genome. All nucleotides in the coding exons and their flanking splice junctions are sequenced to a read coverage of greater than 20X.  The sequence data are assembled and compared to the published genomic reference sequence.  Sanger sequencing is performed if necessary to ensure complete nucleotide coverage of the target sequence and to confirm all reported variants.

Analytical Volume: None specified

Limitations:

Send Out Instructions

 

Reference Test Name: Arterial Aneurysm Panel
Reference Test Number:

None specified

Instructions:

Use a UW Genetics Clinical Lab request form. Send to: Peter Byers MD, 

Collagen Diagnostic Laboratory

Room H-561 Health Science Bldg.
1959 NE Pacific Street, University of Washington
Seattle, WA 98195-7655

Or send with the UW/HMC courier, Mon - Fri at 0900 and 1600. Send refrigerated with UW Courier.