Sign in →

Test Code WBC CoQ10 CoEnzyme Q10 Level, Leukocytes

Clinical System Name

CoEnzyme Q10 Level, Leukocytes

Synonyms

Leukocyte, Intracellular Coenzyme Q10

Ubiquinone
 

Description

Coenzyme Q10 is produced by the body and is necessary for basic cell functioning. Deficiencies in coenzyme Q10 can be primary or secondary. Primary coenzyme Q10 deficiency is a rare autosomal recessive genetic condition with clinically heterogeneous presentation that can include:

  •     encephalopathy
  •     seizures
  •     ataxia
  •     cardiomyopathy
  •     renal failure
  •     cerebellar atrophy
  •     Leigh Syndrome
  •     growth retardation
  •     delayed motor development
  •     lactic acidemia
  •     hypergonadotropic hypogonadism/myopathy

These individuals will have decreased levels of coenzyme Q10 in plasma as well as in skeletal muscle. Secondary coenzyme Q10 deficiency has been seen in individuals with several chronic disorders such as heart conditions, muscular dystrophies, and mitochondrial disorders (such as MELAS and Kearns-Sayre). Additionally, some prescription drugs can lead to a decrease in coenzyme Q10 levels.

Sample Requirements

Specimen: Whole Blood

Container(s): Yellow Top/ACD

Preferred Vol: 5 mL

Minimum Vol: 3 mL

 

Notes: An ACD tube can be obtained from the lab.  Tube can be either ACD solution A or B, both are acceptable.

Processing Instructions

Reject due to: Gold Tops unacceptable. Hemolysis unacceptable.

Spin: N

Aliquot: N

Temp: 2-8 C

Storage location: Affix large Cerner labels to tubes and place in room temp send-outs rack. If Sample is collected Fri-Sun place, in refrigerator. Store extra labels and copy of requisition in the clear plastic box attached to CPA refrigerator. Alert Send-outs team.

 

Off-site collection: Send whole blood refrigerated.

Stability

Specimen Type Temperature Time
Whole blood Room temp 3 d
Whole blood Refrigerated 5 d
Whole blood Frozen N

 

Availability

STAT TAT
N 2 w

 

Performing Laboratory

Medical Neurogenetics

Department

Department:  Medical Neurogenetics, 5424 Glenridge Dr, Atlanta, GA 30342

Phone Number: (678) 225-0222 ext 201

 

Reference Range

Interpretive report is provided.

Methodology

Method: Analyte quantitation

Analytical Volume:

Limitations:

CPT Codes

82542x1 (TLZ 04/08/16)

Special Instructions

Links to:

Medical Neurogenetics

 

Send Out Instructions

Reference Test Name: CoQ10 (Leukocytes)
Reference Test Number: MET04
Instructions: Ship at room temperature, avoid freezing sample. Send overnight via FedEX. Medical Neurogenetics Lab does accept Priority Delivery on a Saturday for this test.