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Test Code ASDNaseT Anti-DNase B Titer, Serum

Useful For

Demonstration of acute or recent streptococcal infection

Reporting Name

Anti-DNase B Titer, S
Seattle Children's Hospital Note:

Clinical System name: Anti DNase B Titer

Specimen Type


Specimen Required


Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 1 mL

Additional Information: Fasting preferred but not required.

Seattle Children's Hospital Note:

Collect 2.0 mL whole blood in a gold or red top.

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  14 days
  Ambient  7 days

Reject Due To


Mild OK; Gross OK


Mild OK; Gross reject


Mild OK; Gross OK



Reference Values

<5 years: ≤250 U/mL

5-17 years ≤375 U/mL

≥18 years: ≤300 U/mL

Method Description

Nephelometry. Polystyrene particles are coated with streptolysin O and DNase B antigens. The serum specimens containing antibodies will complex with the antigens, forming aggregations that will scatter light. The intensity of the resulting scattered light in the nephelometer is dependent upon the antibody content in the specimen. Calculations are based on the comparison of the specimens to standards of known concentrations.(Pacifico L, Mancuso G, Properzi E, et al: Comparison of nephelometric and hemolytic techniques for determination of antistreptolysin O antibodies. Am J Clin Pathol 1995 April;103[4]:396-399)

Day(s) and Time(s) Performed

Monday through Saturday; Continuously until 3 p.m.

Seattle Children's Hospital Note:

TAT: 3 - 5 days

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
ADNAS Anti-DNase B Titer, S 5133-4


Result ID Test Result Name Result LOINC Value
ADNAS Anti-DNase B Titer, S 5133-4

Method Name