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Test Code CHEM CSF CSF Glucose + Protein

Important Note

Simultaneous blood glucose levels are recommended.

Clinical System Name

CSF Glucose + Protein


CSF glucose may be done to diagnose tumors, infections, inflammation of the central nervous system, delirium, and other neurological and medical conditions.


Diseases that interrupt the integrity of the capillary endothelial barrier can lead to an increase in total CSF protein.  CSF protein is generally increased in all types of meningitis, cerebral infarction, brain abscess, meningovascular syphilis, subarachnoid hemorrhage, some brain tumors, trauma to the brain, some cases of multiple sclerosis, encephalomyelitis, and degenerative neurologic diseases. A decreased CSF protein may occur in water intoxication, CSF leak (CSF rhinorrhea or otorrhea), and hyperthyroidism.

Sample Requirements

Specimen: CSF

Container(s):  CSF Tube, Sterile Screw-Capped Container, Sterile Screw-Capped Tube or Syringe

Preferred Vol:  1.0 mL

Minimum Vol: 1.0 mL

Note: Note collection type on requisition and container (e.g. "LP" for CSF lumbar puncture.) Send to the lab immediately (within 1 hour) for accurate results.

Processing Instructions

Reject due to: Age of specimen/incorrect strorage temperature

Spin: Y

Aliquot: Y

Temp:  2-8oC

Storage location:  Core 5 Chemistry Refrigerator


Off-site collection:  Simultaneous blood glucose levels are recommended.  Centrifuge specimen. If visible blood is present, remove supernate from red cells. Refrigerate specimen 2-8oC in a sealed sterile container.



Specimen Type Temperature Time

 4 H

CSF 2-8oC

 3 D

CSF -20oC or -70oC

180 D



STAT Performed TAT
Y 24/7 1 H


Performing Laboratory

Seattle Children's Laboratory    


Department:  Core Chemistry

Phone Number: 206-987-2617

Reference Range

Normal CSF glucose is 45 - 60% of serum glucose measured at the same time.




Age mG/dL
< 1 M Up to 120
1 - 3 M Up to 75
> 3 M Up to 40



Method:  Colorimetric method by Vitros 4600

Analytical Volume:  0.02 mL + 0.03 mL dead space

CPT Codes