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Histoplasma Antibody, Spinal Fluid

Reporting Name

Histoplasma Ab, CSF
Seattle Children's Hospital Note:

Clinical System Name: Miscellaneous Test

Useful For

Aiding in the diagnosis of Histoplasma meningitis

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type


Specimen Required

Container/Tube: Sterile vial

Specimen Volume: 1 mL

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
CSF Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

Mycelial by CF: negative (positives reported as titer)

Yeast by CF: negative (positives reported as titer)

Antibody by immunodiffusion: negative (positives reported as band present)

Day(s) and Time(s) Performed

Monday through Friday; 9:30 a.m.

Test Classification

This test uses a standard method. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

86698 x 3

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CHIST Histoplasma Ab, CSF In Process


Result ID Test Result Name Result LOINC Value
15118 Histoplasma Mycelial (CSF) 27220-3
15119 Histoplasma Yeast (CSF) 27209-6
15120 Histoplasma Immunodiffusion (CSF) 21330-6

Method Description

Both immunodiffusion and compliment fixation (CF) tests are used to detect antibodies to Histoplasma capsulatum. For immunodiffusion, the antigen is a culture filtrate, histoplasmin. H and M precipitin bands are identified. For the CF test, the antigens are histoplasmin and a yeast form of Histoplasma capsulatum; the latter is more sensitive.(Roberts GD: Fungi. In Laboratory Procedures in Clinical Microbiology. Second edition. Edited by JA Washington II. New York, Springer-Verlag, 1985)

Reject Due To


Mild OK; Gross OK


Mild OK; Gross OK





Method Name

Complement Fixation (CF)/Immunodiffusion