Sign in →

Test Code COPPER U Copper, 24 Hour, Urine

Reporting Name

Copper, 24 Hr, U

Useful For

Investigation of Wilson disease and obstructive liver disease using a 24-hour urine specimen


Advisory Information


 



Necessary Information


24-Hour volume is required.



Specimen Required


Patient Preparation: High concentrations of barium are known to interfere with this test. If barium-containing contrast media has been administered, a specimen should not be collected for 96 hours.

Supplies: Urine Tubes, 10 mL (T068)

Collection Container/Tube: Clean, plastic urine collection container with no metal cap or glued insert

Submission Container/Tube: Plastic urine tube (T068) or clean, plastic aliquot container with no metal cap or glued insert

Specimen Volume: 10 mL

Collection Instructions:

1. Collect urine for 24 hours.

2. Refrigerate specimen within 4 hours of completion of 24-hour collection.

3. See Trace Metals Analysis Specimen Collection and Transport in Special Instructions for complete instructions.

Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens in Special Instructions for multiple collections.


Specimen Type

Urine

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Day(s) and Time(s) Performed

Tuesday, Thursday; 8 a.m.

Seattle Children's Hospital Note:

TAT: 3 - 8 days

Performing Laboratory

Mayo Medical Laboratories in Rochester

Method Name

Inductively Coupled Plasma-Mass Spectrometry

Method Description

This assay is performed on an inductively coupled plasma-mass spectrometer in dynamic reaction cell mode. Calibration standards and blanks are diluted with an aqueous acidic diluent containing internal standards. Quality control specimens and patient specimens are diluted in an identical manner. In turn, all diluted blanks, calibrating standards, quality control specimens and patient specimens are aspirated into a pneumatic nebulizer and the resulting aerosol directed to the hot plasma discharge by a flow of argon. In the annular plasma the aerosol is vaporized, atomized, then ionized. The ionized gases plus neutral species formed in the annular plasma space are aspirated from the plasma through an orifice into a quadrupole mass spectrometer. The mass range from 1 to 263 amu is rapidly scanned multiple times and ion counts tabulated for each mass of interest. Instrument response is defined by the linear relationship of analyte concentration versus ion count ratio (analyte ion count/internal standard ion count). Analyte concentrations are derived by reading the ion count ratio for each mass of interest and determining the concentration from the response line.(Unpublished Mayo method)

Reference Values

0-17 years: not established

≥18 years: ≤60 mcg/24h

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

82525

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CUU Copper, 24 Hr, U 5633-3

 

Result ID Test Result Name Result LOINC Value
8590 Copper, 24 Hr, U 5633-3
TM7 Collection Duration 13362-9
VL4 Urine Volume 3167-4

Reject Due To

Hemolysis

NA

Lipemia

NA

Icterus

NA

Other

NA

Urine Preservative Collection Options

Ambient

Yes

Refrigerated

Preferred

Frozen

Yes

6N HCl

Yes

50% Acetic Acid

Yes

Na2CO3

No

Toluene

Yes

6N HNO3

Yes

Boric Acid

No

Thymol

No

Forms

If not ordering electronically, complete, print, and send a Gastroenterology and Hepatology Test Request Form (T728) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/gastroenterology-and-hepatology-test-request.pdf)