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Test Code Chromium Chromium, Serum

Reporting Name

Chromium, S

Useful For

Screening for occupational exposure

 

Monitoring metallic prosthetic implant wear


Specimen Required


Patient Preparation: High concentrations of gadolinium and iodine are known to interfere with most metals tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.

Supplies:

Metal Free B-D Tube (No Additive), 6 mL (T184)

Metal Free Specimen Vial (T173)

Collection Container/Tube: Plain, royal blue-top Vacutainer plastic trace element blood collection tube (T184)

Submission Container/Tube: 7-mL Mayo metal-free, screw-capped, polypropylene vial (T173)

Specimen Volume: 1.6 mL

Collection Instructions:

1. Allow the specimen to clot for 30 minutes; then centrifuge the specimen to separate serum from the cellular fraction.

2. Remove the stopper. Carefully pour specimen into a Mayo metal-free, polypropylene vial, avoiding transfer of the cellular components of blood. Do not insert a pipet into the serum to accomplish transfer, and do not ream the specimen with a wooden stick to assist with serum transfer.

3. See Trace Metals Analysis Specimen Collection and Transport in Special Instructions for complete instructions.

Additional Information: If ordering the trace element blood collection tube from BD, order catalog #368380.


Seattle Children's Hospital Note:

Collect 3.2 mL whole blood in Navy Blue Top trace element tube. (Lawson #11930)

 

Processing Note: Use of a standard pipette is acceptable for aliquoting these samples.

Specimen Type

Serum

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Day(s) and Time(s) Performed

Monday, Wednesday, Friday; 8 a.m.

Seattle Children's Hospital Note:

TAT: 3 - 6 days

Performing Laboratory

Mayo Medical Laboratories in Rochester

Method Name

Dynamic Reaction Cell-Inductively Coupled Plasma-Mass Spectometry (DRC-ICP-MS)

Method Description

Chromium (Cr) in serum is analyzed by inductively coupled plasma-mass spectometry (ICP-MS) in dynamic reaction cell (DRC) mode using rhodium (Rh) as an internal standard and a salt matrix calibration.(Unpublished Mayo method)

Reference Values

<0.3 ng/mL

When collected by a phlebotomist experienced in ultra-clean collection technique and handled according to the instructions in Trace Metals Analysis Specimen Collection and Transport in Special Instructions, we have observed the concentration of chromium in serum to be <0.3 ng/mL. However, the majority of specimens submitted for analysis from unexposed individuals contain 0.3 ng/mL to 0.9 ng/mL of chromium. Commercial evacuated blood collection tubes not designed for trace-metal specimen collection yield serum containing 2.0 ng/mL to 5.0 ng/mL chromium derived from the collection tube.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

82495

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CRS Chromium, S 5622-6

 

Result ID Test Result Name Result LOINC Value
8638 Chromium, S 5622-6

Reject Due To

Hemolysis

Mild OK; Gross OK

Lipemia

Mild OK; Gross OK

Icterus

Mild OK; Gross OK

Other

NA