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Test Code F8 Inversion Factor 8 Inversion DNA

Clinical System Name

Factor 8 Inversion DNA


DNA Factor VIII Inversion

Bloodworks Northwest F8 Inversion

Sample Requirements

Specimen: Whole Blood

Container(s): Lavender/EDTA

Preferred Vol: 10 mL

Minimum Vol: 5 mL


Note: BWNW Hemostasis Requisition must be completed and accompany specimen to lab. Send tubes to lab immediately. 

Whole blood shipped at 4oC or ambient temperature is acceptable and should arrive in the lab within 48 hours.

Analysis of amniocytes can be performed on cultured amniocytes. Two T-25 flasks of cells cultured to confluency will be accepted.


Processing Instructions

Reject due to:

Spin: N

Aliquot: N

Temp: RT

Storage location: Give whole blood to Send Outs. Store extra labels and copy of requisition in the send outs box attached to CPA refrigerator.


Off-site collection:


STAT Performed TAT
N Daily 5-10 d


Performing Laboratory

Bloodworks Northwest

Hemostasis Laboratory
921 Terry Ave
Seattle WA 98104

Phone: (206) 689-6594



Department: Send Outs

Phone: (206) 987-2563

Reference Range

Interpretive report provided.


Method: polymerase chain reaction (PCR) based

Clinical Utility

In severe hemophilia A, a common recurrent intron 22 gene inversion accounts for ~45% of the cases. A recurrent intron 1 inversion accounts for ~5% of the cases. These two sites are the first to be screened for severe hemophilia A patients.

Send Out Instructions

Reference Test Name: DNA Factor VIII Inversion
Reference Test Number: 3250-05
Instructions: Send sample and requisition to Bloodworks Northwest via courier. Needs to arrive within 48 hours.