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Test Code HistoplAb Histoplasma Antibody, Serum

Reporting Name

Histoplasma Ab, S
Seattle Children's Hospital Note:

Clinical System Name:  Histoplasma Antibody

Useful For

Aiding in the diagnosis of active histoplasmosis

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type


Specimen Required


Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.5 mL

Seattle Children's Hospital Note:

Collect 1 mL whole blood in a Red or Gold Top.

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

Mycelial by CF: negative (positives reported as titer)

Yeast by CF: negative (positives reported as titer)

Antibody by immunodiffusion: negative (positives reported as band present)

Day(s) and Time(s) Performed

Monday through Friday; 9:30 a.m.

Test Classification

This test uses a standard method. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

86698 x 3

LOINC Code Information

Result ID Test Result Name Result LOINC Value
15121 Histoplasma Mycelial 20573-2
15122 Histoplasma Yeast 20574-0
15123 Histoplasma Immunodiffusion 5218-3

Method Description

Both immunodiffusion and complement fixation (CF) tests are used to detect antibodies to Histoplasma capsulatum. For immunodiffusion, the antigen used is a culture filtrate. Histoplasmin H and M precipitins can be identified by the assay. For the CF test, antigens are histoplasmin and a yeast form antigen of Histoplasma capsulatum; the latter is more sensitive.(Roberts GD: Fungi. In Laboratory Procedures in Clinical Microbiology. Second edition. Edited by JA Washington II. New York, Springer-Verlag, 1985)

Reject Due To


Mild OK;Gross reject


Mild OK;Gross reject





Method Name

Complement Fixation (CF)/Immunodiffusion