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Test Code IL2R Soluble Interleukin-2R Level

Important Note

Samples should be drawn Monday - Thursday 4 AM - 1330 PM preferably. (Note: It is acceptable to draw outside these hours or on a holiday, sample MUST then be spun down and plasma frozen)

Clinical System Name

Soluble Interleukin-2R Level




A soluble form of IL-2R appears in serum and plasma, concomitant with its increased expression on cells. Increased levels of the soluble IL-2R in biological fluids correlate with activation of T and / or B cells.  Results of a number of studies suggest a correlation of levels of IL-2R in serum with disease activity in autoimmune and infectious disorders as well as in transplantation rejection. Markedly increased IL-2sR levels have been associated with hematologic malignancies. Levels of IL-2R correlate with tumor burden and response to therapy in numerous malignancies. IL-2R levels can be used to predict the long-term prognosis in non-Hodgkin’s lymphoma patients and to assess the status of patients with HIV and acquired immunodeficiency.

Sample Requirements

Specimen: Whole Blood

Container(s): Lavender Top/EDTA

Preferred Vol: 3 mL

Minimum Vol: 1 mL


Notes: Samples should be drawn Monday - Thursday 4 AM - 1330 PM preferably. (Note: It is acceptable to draw outside these hours, sample must then be spun down and plasma frozen). Send tubes to lab immediately. Whole blood samples MUST reach the reference lab within 24 hours of the blood draw.  May share WHOLE BLOOD sample with Perforin/Granzyme B.


Processing Instructions

Reject due to: Whole blood not spun down and plasma not frozen within 24 hours.

Spin: See Comments Below

Aliquot: See Comments Below

Temp: Whole Blood: RT, Plasma: -20 C 

Storage location: If drawn M - Th between 4 am and 1330 pm then affix large Cerner labels to whole blood tube(s) and place in room temp send-outs rack. Alert Send-outs team.  If drawn evenings, weekends or holidays sample must be spun down within 24 hours and plasma frozen.


Off-site collection: Spin down and freeze plasma. Transport frozen.


Specimen Type Temperature Time
Whole blood Room temp 24 h
Plasma - 20 C 1 w



N 3 - 5 d


Performing Laboratory

Cincinnati Children’s Diagnostic Immunology Laboratories



Cincinnati Children’s Diagnostic Immunology Laboratories

3333 Burnet Ave

Cincinnati, OH 45229


Phone Number:

(513) 636-4685

Reference Range

Interpretive report is provided.


Method: Chemiluminescent Immunoassay

Analytical Volume:


CPT Codes


Send Out Instructions

Reference Test Name: Soluble IL-2R
Reference Test Number: None specified.
Instructions: Send FedEX PRIORITY Overnight to Cincinnati Children's at room temperature (dry ice if frozen plasma).