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Test Code LPA Lipoprotein (a), Serum

Reporting Name

Lipoprotein (a), S

Useful For

Cardiovascular disease (CVD) risk refinement in patients with moderate or high risk based on conventional risk factors

Specimen Required

Patient Preparation: Fasting-overnight (12-14 hours)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Seattle Children's Hospital Note:

Draw 2.0 mL whole blood in a Red top.

Specimen Type


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 7 days
  Frozen  7 days

Day(s) and Time(s) Performed

Monday through Saturday; Continuously

Performing Laboratory

Mayo Medical Laboratories in Rochester

Method Name

Automated Turbidimetric Immunoassay

Method Description

This test uses an automated turbidimetric immunoassay method to measure lipoprotein (a) (Lp[a]) in serum. Serum is first incubated with a polymeric enhancer. Following initial incubation and measurement of specimen blank, undiluted antiserum specific to human Lp(a) is added. The specimen solution is mixed and insoluble antigen-antibody complexes begin to form. The complexes that form produce turbidity in the mixture and increase the amount of light scatter. The decrease in percent transmittance of light is measured and is proportional to the amount of Lp(a) in the specimen.(Levine DM, Sloan DJ, Donner JE, et al: Automated measurement of lipoprotein[a] by immunoturbidimetric analysis. Int J Clin Lab Res 1992;22:173-178)

Reference Values

≤30 mg/dL

Values >30 mg/dL may suggest increased risk of coronary heart disease.


For SI unit Reference Values, see

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
LIPA Lipoprotein (a), S 10835-7


Result ID Test Result Name Result LOINC Value
LIPA Lipoprotein (a), S 10835-7

Reject Due To


Mild OK; Gross reject


Mild OK; Gross reject


Mild OK; Gross reject





If not ordering electronically, complete, print, and send a Cardiovascular Test Request Form (T724) with the specimen (