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Test Code METANEP PL Metanephrines, Fractionated, Free, Plasma

Reporting Name

Metanephrines, Fract., Free, P

Useful For

Screening test for presumptive diagnosis of catecholamine-secreting pheochromocytomas or paragangliomas

Specimen Required

Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Seattle Children's Hospital Note:

Collect 2.0 mL whole blood in a Lavender top.

Spin and aliquot 1 mL plasma.

Specimen Type

Plasma EDTA

Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma EDTA Frozen (preferred) 14 days
  Refrigerated  7 days

Day(s) and Time(s) Performed

Monday through Saturday; 1 p.m.

Not reported on Sunday

Seattle Children's Hospital Note:

TAT: 4 - 6 days

Performing Laboratory

Mayo Medical Laboratories in Rochester

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Method Description

Free metanephrine and normetanephrine are extracted from plasma using solid phase extraction. The concentrated eluate is analyzed using liquid chromatography-tandem mass spectometry (LC-MS/MS) and quantified using stable isotope-labeled internal standards, d(3)-metanephrine and d(3)-normetanephrine.(Taylor RL, Singh RJ: Validation of liquid chromatography-tandem mass spectrometry method for analysis of urinary conjugated metanephrine and normetanephrine for screening of pheochromocytoma. Clin Chem 2002 Mar;48[3]:533-539)

Reference Values


<0.50 nmol/L



<0.90 nmol/L

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
PMET Metanephrines, Fract., Free, P 57772-6


Result ID Test Result Name Result LOINC Value
10140 Normetanephrine, Free 40851-8
10139 Metanephrine, Free 49700-8

Reject Due To


Mild OK; Moderate-reject if hemoglobin concentration is >250 mg/dL


Mild OK; Gross OK


Mild OK; Gross OK




If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

General Request Form (T239) (

Oncology Test Request Form (T729) (