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Test Code NBLOH Neuroblastoma Loss of Heterozygosity

Important Note

Tumor tissue AND a normal sample is required.

Tumor sample collected during or after treatment (e.g. post-chemotherapy) CANNOT be accepted. Pre-treatment relapse tumor samples can be submitted.

Clinical System Name

Neuroblastoma Loss of Heterozygosity


Neuroblastoma LOH

Sample Requirements

Specimen: Whole Blood

Container(s): Lavender/EDTA

Preferred Vol: 4 mL

Minimum Vol:



Specimen: Tumor

Container(s): Sterile Screw-Capped Container

Preferred Vol:

Minimum Vol:



Note: at least 40% tumor must be present in the submitted tumor sample

Processing Instructions

Reject due to:

Spin: N

Aliquot: N

Temp: Refrigerate whole blood and immediately freeze tumor

Storage location: Deliver blood to CPA refrigerator Send Outs rack and deliver Tumor to CPA -70 freezer Send Outs rack.


Off-site collection:


Specimen Type Temperature Time
Whole Blood Room temp 24 h
  Refrigerated 72 h
  Frozen N
Tumor Room Temp N
  Refrigerated N
  Frozen 24 h



STAT Performed TAT
N Monday to Friday 3 wks


Performing Laboratory

Nationwide Children's Hospital


700 Children's Drive

Columbus, OH 43205


Phone Number: (614) 722-5321


Department: Send Outs

Phone Number: (206) 987-2563

Reference Range

Interpretive report is provided


This array evaluates for the following clinically significant aberrations within the cancer genome for Neuroblastoma:

  • Losses of 1p, 3p, 4p and 11q
  • Gains of 1q, 2p and 17q
  • Loss of Heterozygosity involving 1p, 3p, 4p and 11q
  • Gains of whole chromosomes will also be detected with the assay.

Information regarding other chromosome regions will not be reported, as their clinical significance in neuroblastoma is currently unknown

Send Out Instructions

Reference Test Name: Targeted Oncology Microarray
Reference Test Number: TONCMA
Instructions: Ship whole blood overnight, ambient temperature. Ship tumor on dry ice.