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Test Code NBLOH Neuroblastoma Loss of Heterozygosity

Important Note

Tumor tissue AND a normal sample is required.

Tumor sample collected during or after treatment (e.g. post-chemotherapy) CANNOT be accepted. Pre-treatment relapse tumor samples can be submitted.

Clinical System Name

Neuroblastoma Loss of Heterozygosity

Synonyms

Neuroblastoma LOH

Sample Requirements

Specimen: Whole Blood

Container(s): Lavender/EDTA

Preferred Vol: 4 mL

Minimum Vol:


AND

 

Specimen: Tumor

Container(s): Sterile Screw-Capped Container

Preferred Vol:

Minimum Vol:

 

 

Note: at least 40% tumor must be present in the submitted tumor sample

Processing Instructions

Reject due to:

Spin: N

Aliquot: N

Temp: Refrigerate whole blood and immediately freeze tumor

Storage location: Deliver blood to CPA refrigerator Send Outs rack and deliver Tumor to CPA -70 freezer Send Outs rack.

 

Off-site collection:

Stability

Specimen Type Temperature Time
Whole Blood Room temp 24 h
  Refrigerated 72 h
  Frozen N
Tumor Room Temp N
  Refrigerated N
  Frozen 24 h

 

Availability

STAT Performed TAT
N Monday to Friday 3 wks

 

Performing Laboratory

Nationwide Children's Hospital

ChildLab

700 Children's Drive

Columbus, OH 43205

 

Phone Number: (614) 722-5321

Department

Department: Send Outs

Phone Number: (206) 987-2563

Reference Range

Interpretive report is provided

Methodology

This array evaluates for the following clinically significant aberrations within the cancer genome for Neuroblastoma:

  • Losses of 1p, 3p, 4p and 11q
  • Gains of 1q, 2p and 17q
  • Loss of Heterozygosity involving 1p, 3p, 4p and 11q
  • Gains of whole chromosomes will also be detected with the assay.

Information regarding other chromosome regions will not be reported, as their clinical significance in neuroblastoma is currently unknown

Send Out Instructions

Reference Test Name: Neuroblastoma Loss of Heterozygosity (LOH)
Reference Test Number: NBLLOH
Instructions: Ship whole blood overnight, ambient temperature. Ship tumor on dry ice.