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Test Code Neurotran Neurotransmitter Metabolites, CSF

Important Note

Specimens collected for this test may also be used for 5-Methyltetrahydrofolate, CSF Neopterin, and/or CSF Tetrahydrobiopterin/Neopterin profile - all performed at the same reference laboratory. Separate CSF specimens should be submitted for all other testing.

CPA: The MNG CSF Collection Tubes can be found in the yellow bucket on the top shelf of the CPA refrigerator.

Clinical System Name

Neurotransmitter Metabolites, CSF

Sample Requirements

Specimen: Cerebrospinal Fluid

Container(s): See Comments

Preferred Vol: 4.5 mL

Minimum Vol: 1.5 mL split between tubes #1 - #3 (0.5 mL each; run the risk of not being able to add other testing)

 

Note: Call the Main Lab for appropriate specimen collection containers. Each set consists of five numbered micro-centrifuge tubes. One complete set of tubes is required per patient. Fill each tube to the marked line. Place the tubes on ice at the bedside immediately after collection. Hand deliver specimens to the Main Lab immediately.

Processing Instructions

Reject due to:

Spin: N

Aliquot: N

Temp: -70 C

Storage Location: LAB ASSISTANTS: give specimens to the Send Outs department immediately. IF SEND OUTS NOT AVAILABLE: If the sample is blood contaminated, the tubes should immediately be centrifuged and the clear CSF transferred to new similarly labeled tubes. Freeze all five specimen tubes together in the -70 freezer Send Outs rack ASAP following collection.

 

Off-site Collection: No off-site collection.

Stability

Specimen Type Temperature Time
CSF Room temp Unacceptable
  Refrigerated Unacceptable
  Frozen Y

 

Availability

STAT Performed TAT
  Collect M - F 0800-1630  10 - 14 d

 

Performing Laboratory

Medical Neurogenetics (MNG) Laboratories

5424 Glenridge Drive NE

Atlanta, GA 30342

 

Phone: (678) 225-0222

Department

Department: Send Outs

Phone: (206) 987-2563

Reference Range

AGE (Years) 5-HIAA nmol/L HVA nmol/L 3-O-MD nmol/L
0 - 0.2 208-1159 337-1299 <300
0.2 - 0.5 179-711 450-1132 <300
0.5 - 2.0 129-520 294-1115 <300
2.0 - 5.0 74-345 233-928 <150
5.0 - 10 66-338 218-852 <100
10 - 15 67-189 167-563 <100
Adults 67-140 145-324 <100

 

Interpretation provided by reference laboratory.

Methodology

Method: HPLC/Electrochemistry

Analytical Volume: 3.5 mL CSF

Limitations:

 

CPT Codes

82542, 83497, 83150

Send Out Instructions

Reference Test Name: Neurotransmitter Metabolites (5HIAA, HVA, 30MD, CSF)
Reference Test Number: NC04
Instructions:

If the sample is blood contaminated, the tubes should be centrifuged immediately and the clear CSF should be transferred to new, similarly labeled tubes. Freeze all five specimen tubes together in the -70 freezer Send Outs rack ASAP after collection. Ship on dry ice via FedEx Priority Overnight.

 

Note: Saturday deliveries are acceptable.