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Test Code PREALB Prealbumin

Clinical System Name





Prealbumin (thyroxin-binding prealbumin, transthyretin) transports the thyroid hormones thyroxin (T4) and triiodothyronine (T3), as well as Vitamin A. Prealbumin is a negative acute-phase reactant with decreased levels found in inflammation, malignancy, cirrhosis of the liver, and protein-wasting diseases of the gut or kidneys. Increased concentrations can be seen in Hodgkin’s disease or a prealbumin-producing tumor. Prealbumin may also be used as a sensitive indicator of nutritional status.

Sample Requirements

Specimen:  Whole Blood

Container(s): Gold SST, Dark Green/Sodium Heparin, Red

Preferred Vol:1 mL

Minimum Vol:  1 Gold Microtainer or 1 Lt. Green/Li Heparin Microtainer


Note: A fasting sample is preferable.  Method is affected by patient not fasting, lipemia, and EDTA. Not affected by hemolysis, icterus, or heparin. Can assay Prealbumin and RBP on the same sample.


Processing Instructions

Reject due to: Insufficient Quantity

Spin: Y

Aliquot: Y

Temp:  2-4oC

Storage location:  Core Chemistry Refrigerator


Off-site collection:  A fasting sample is preferable. Spin blood, refrigerate serum or plasma.



Specimen Type Temperature Time
Serum or Plasma RT

24 H

Serum or Plasma 2-4oC

14 D

Serum or Plasma -20o C or -70oC

Not Recommended



STAT Performed TAT
Y 24/7 1 H


Performing Laboratory

Seattle Children's Laboratory    


Department:  Core Chemistry

Phone Number: 206-987-2617


Reference Range


0 - 2 weeks 10 - 13
2 weeks - 6 Years 13 - 25
6 - 16 Years 16 - 28
16 Years - Adult 18 - 45

Premature newborns are expected to have a lower prealbumin level than full term newborns.


Method: Nephelometry by Vitros 4600

Analytical Volume:  0.25 mL serum or plasma

CPT Codes