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Test Code PROT CSF CSF Protein

Clinical System Name

CSF Protein


Diseases that interrupt the integrity of the capillary endothelial barrier can lead to an increase in total CSF protein.  CSF protein is generally increased in all types of meningitis, cerebral infarction, brain abscess, meningovascular syphilis, subarachnoid hemorrhage, some brain tumors, trauma to the brain, some cases of multiple sclerosis, encephalomyelitis, and degenerative neurologic diseases. A decreased CSF protein may occur in water intoxication, CSF leak (CSF rhinorrhea or otorrhea), and hyperthyroidism.

Sample Requirements

Specimen: CSF

Container(s): CSF Tube, Sterile Screw-Capped Container, Sterile Screw-Capped Tube or Syringe

Preferred Vol:  1 mL

Minimum Vol: 1 mL

Note: Note collection type on requisition and container (e.g. "LP" for CSF lumbar puncture.) Send to the lab immediately (within 1 hour) for accurate results.



Processing Instructions

Reject due to: Insufficient volume, age of specimen

Spin: Y

Aliquot: Y

Temp: 2-8oC

Storage location: Core 5 Chemistry Refrigerator


Off-site collection: Centrifuge specimen. If visible blood is present, remove supernate from red cells. Refrigerate specimen 2-8oC in a sealed sterile container.



Specimen Type Temperature Time

 4 H

CSF 2-8oC

 3 D

CSF -20oC or -70oC

180 D



STAT Performed TAT
Y 24/7 1 H


Performing Laboratory

Seattle Children's Laboratory    


Department:  Core Chemistry

Phone Number: 206-987-2617

Reference Range


Age mG/dL
< 1 M Up to 120
1 - 3 M Up to 75
> 3 M Up to 40



Method:  Colorimetric method by Vitros 4600

Analytical Volume:  0.02 mL + 0.03 mL dead space

CPT Codes