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Test Code PTH-RP Parathyroid Hormone-Related Peptide (PTHrP), Plasma

Reporting Name

PTH-Related Peptide

Useful For

Diagnostic workup of patients with suspected hypercalcemia of malignancy


Diagnostic workup of patients with hypercalcemia of unknown origin

Specimen Required

Patient Preparation: None required

Collection Container/Tube: Ice-cooled, lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 0.7 mL

Collection Instructions: Spin specimen down in a refrigerated centrifuge or in chilled centrifuge cups.

Specimen Type

Plasma EDTA

Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma EDTA Frozen 90 days

Day(s) and Time(s) Performed

Monday, Wednesday, Thursday ; 2 p.m.


Seattle Children's Hospital Note:

TAT: 4 - 7 days

Performing Laboratory

Mayo Medical Laboratories in Rochester

Method Name

Immunochemiluminometric Assay (ICMA)

Method Description

The PTHrP assay recognizes the amino-terminal fragment of the PTHrP peptide. The test is performed by an immunochemiluminometric assay by using 2 affinity-purified antibodies from a goat immunized with (1-86) parathyroid hormone-related peptide (PTHrP). One batch of the purified antibody is labeled with acridinium ester as tracer antibodies; a second batch of purified antibody is immobilized onto the bead. When the plasma specimen has PTHrP, the tracer antibodies are linked to the bead via PTHrP and the immobilized antibody.(Wu TJ, Taylor RL, Kao PC: Parathyroid hormone-related peptide immunochemiluminometric assay. Developed with polyclonal antisera produced from a single animal. Ann Clin Lab Sci 1997;27:384-390)

Reference Values

<2.0 pmol/L

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
PTHRP PTH-Related Peptide 15087-0


Result ID Test Result Name Result LOINC Value
81774 PTH-Related Peptide 15087-0

Reject Due To


Mild OK; Gross OK


Mild OK; Gross OK


Mild OK; Gross OK