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Test Code TPMT GEN TPMT Genetics Assessment

Clinical System Name

TPMT Genetics Assessment

Synonyms

Pro-PredictR TPMT Genetics AssessmentTBG

Thiopurine Methyltransferase, Genetics Assessment

6-mercaptopurine

6-MP

6-TG

6-thioguanine

AZA toxicity

Azathioprine

S-adenosyl-L-methionine genotype

Thioguanine

Thiopurine

Thiopurine S-methyltransferase genotype

TPMT genetics

TPMT mutation

Description

TPMT Genetics is an analysis to determine a person's ability to produce thiopurine methyltransferase (TPMT) activity to identify patients at risk for acute toxicity from 6-MP or azathioprine. The distribution of TPMT activity is trimodal; homozygous normal (89%), heterozygous (11%), and homozygous recessive (0.3%). Approximately 1 in 1213 individuals may have a low TPMT enzyme activity (homozygous low) resulting from known and theoretical mutations that are not included in this panel.

Sample Requirements

Specimen: Whole Blood

Container(s): Lavender/EDTA, Yellow/ACD A, or Yellow/ACD B

Preferred Vol: 3.0 mL

Minimum Vol: 1.0 mL

 

Note:

Processing Instructions

Reject due to: Plasma or serum. Heparinized specimens.

Spin: N

Aliquot: N

Temp: 2 - 4  C

Storage location: Do not spin. Refrigerate whole blood and place in CPA refrigerator, Send Outs rack.

 

Off-site collection: Do not spin. Refrigerate whole blood. Transport refrigerated.

Stability

Specimen Type Temperature Time
Whole blood Room temp 72 h
  Refrigerated 2 w
  Frozen 1 m

 

Availability

STAT Performed TAT
N M and Th 5 - 10 d

 

Performing Laboratory

ARUP Laboratories

500 Chipeta Way
Salt Lake City, UT 84108-1221

 

Phone Number: (800) 522-2787

Department

Department: Send Outs

Phone Number: (206) 987-2563

Reference Range

Interpretive report provided.

Methodology

Method: Polymerase Chain Reaction/Fluorescence Monitoring

Analytical Volume: 1 mL Whole Blood

Limitations:

Send Out Instructions

Reference Test Name: Thiopurine Methyltransferase (TPMT) Genotyping, 4 Variants
Reference Test Number: 2012233
Instructions: Send out Monday - Friday with the ARUP courier.