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Test Code VASO INTES Vasoactive Intestinal Polypeptide (VIP), Plasma

Reporting Name

Vasoactive Intestinal Polypeptide,P

Useful For

Detection of vasoactive intestinal polypeptide producing tumors in patients with chronic diarrheal diseases

Specimen Required

Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Fasting (8 hours)

2. Spin down and immediately freeze.

Additional Information: This test should not be requested on patients who have recently received radioactive material.

Specimen Type

Plasma EDTA

Specimen Minimum Volume

0.55 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma EDTA Frozen 90 days

Day(s) and Time(s) Performed

Monday, Wednesday; 2 p.m.

Seattle Children's Hospital Note:

TAT: 5 - 10 days

Performing Laboratory

Mayo Medical Laboratories in Rochester

Method Name

Radioimmunoassay (RIA)

Method Description

A radioimmunoassay technique is used. Highly purified synthetic human vasoactive intestinal polypeptide (VIP) obtained from Peninsula Laboratories is used as a standard and is also treated with Na-(125)I for use as a labeled antigen. Anti-VIP antibody is produced in rabbits to an antigen prepared by coupling natural VIP from the Karolinska Institute to bovine serum albumin. The antiserum obtained shows no cross reactivity to secretin, gastric inhibitory polypeptide, peptide histidine methionine, glucagon, and motilin up to and including concentrations of 10 ng/mL.(Yaksh TL, Michener SR, Bailey JE, et al: Survey of distribution of substance P, vasoactive intestinal polypeptide, cholecystokinin, neurotensin, metenkephalin, bombesin and PHI in the spinal cord of cat, dog, sloth, and monkey. Peptides 1988;9:357-372)

Reference Values

<75 pg/mL

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
VIP Vasoactive Intestinal Polypeptide,P 3125-2


Result ID Test Result Name Result LOINC Value
8150 Vasoactive Intestinal Polypeptide,P 3125-2

Reject Due To


Mild OK; Gross reject


Mild OK; Gross reject


Mild OK; Gross OK