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HelpBupropion and Hydroxybupropion, Serum or Plasma
Clinical System Name
Miscellaneous Test
Synonyms
Hydroxybupropion
Wellbutrin
Zyban
Sample Requirements
Specimen: Whole Blood
Container(s): Red or Dark Green/Sodium Heparin
Preferred Vol: 6.0 mL
Minimum Vol: 1.2 mL
Note: Do not use serum separator tubes (i.e. Gold/SST). Deliver to Main Lab immediately. Trough levels are most reproducible.
Processing Instructions
Reject due to: Gel-barrier tubes; Specimen received not frozen; Specimen received in Bupropion Analysis Tube containing Sodium Citrate Monobasic
Spin: Y
Aliquot: Y
Temp: -20 C
Storage Location: Freeze within ONE hour of collection. Prepare one aliquot of at least 0.6 mL (minimum) of serum or plasma in a plastic aliquot container and freeze specimen. Store in the CPA -20 freezer, Send Outs rack.
Off-site Collection: Centrifuge and aliquot into a plastic aliquot tube, labeled with a large Cerner label. Freeze the sample and transport frozen to Seattle Children's Main Lab.
Stability
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum or Plasma | Room Temp | Unacceptable |
| Refrigerated | Unacceptable | |
| Frozen | Indefinitely |
Availability
| STAT | Performed | TAT |
|---|---|---|
| Y - for additional fee | Daily | 4 - 7 d |
Performing Laboratory
MedTox Laboratories, Inc.
402 West County Road D
St. Paul, MN 55112
Phone Number: (651) 286-6220
Department
Department: Send Outs
Phone Number: (206) 987-2563
CPT Codes
80338
Methodology
Method: Liquid Chromatography with Tandem Mass Spectrometry (LC/MS-MS)
Analytical Volume: 0.6 mL Serum or Plasma
Limitations:
Reference Range
| nG/mL | Reporting Limit | Critical High | |
| Bupropion | 50 - 100 | 5 nG/mL | 300 nG/mL |
| Hydroxybupropion | 600 - 2000 | 100 nG/mL |
Send Out Instructions
| Reference Test Name: | Bupropion and Hydroxybupropion, Serum or Plasma |
| Reference Test Number: |
178 |
| Instructions: | Send out Monday through Friday via FedEx Priority Overnight. Send frozen sample(s) on dry ice. |