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Aldosterone/Renin Activity Ratio

Clinical System Name

Miscellaneous Test

Synonyms

Aldosterone

Aldosterone and Plasma Renin Activity

Aldosterone serum

Aldosterone/Renin Activity

ARR

ARR-P

PRA

Renin Activity
 

Sample Requirements

Specimen: Whole Blood

Container(s): Gold SST or Red

Preferred Vol: 2.0 mL

Minimum Vol: 1.0 mL

 

AND

 

Specimen: Whole Blood

Container(s): Lavender/EDTA

Preferred Vol: 4 mL

Minimum Vol: 2.4 mL

 

Note:

SUPINE: Obtain sample 0800-1000 AM, fasting starting at midnight, on a normal sodium diet (100-200 mEq/day).

UPRIGHT: Samples obtained before noon (after at least 2 hours in upright position), on a normal sodium diet.

Processing Instructions

Reject due to: Plasma collected in citrate, heparin, or oxalate. Hemolyzed specimens.

Spin: Y

Aliquot: Y

Temp: -20 C

Storage location: CPA -20 freezer, Send Outs rack. CRITICAL FROZEN. Spun plasma must be frozen within one hour.

 

Off-site collection: CRITICAL FROZEN. Spun plasma must be frozen within one hour. Spin blood, aliquot plasma and send frozen. If ordered with other tests, must be received in an individual aliquot container frozen.

Stability

Specimen Type Temperature Time
Plasma Room Temp 6 h
  Refrigerated Unacceptable
  Frozen 1 m
     
Serum Room Temp 8 h
  Refrigerated 5 d
  Frozen 1 m

 

Availability

STAT Performed TAT
N Daily 1 - 5 d

 

Performing Laboratory

ARUP Laboratories

500 Chipeta Way
Salt Lake City, UT 84108-1221

 

Phone Number: (800) 522-2787

Department

Department: Send Outs

Phone Number: (206) 987-2563 

Reference Range

Age Renin Supine (ng/mL/hr) Upright (ng/mL/hr)
Newborn (1 - 7 days) 2.0 - 35.0 NA
Cord Blood 4.0 - 32.0 NA
1 - 12 months 2.4 - 37.0 NA
13 months - 3 years 1.7 - 11.2 NA
4 - 5 years 1.0 - 6.5 ≤15
6 - 10 years 0.5 - 5.59 ≤17
11 - 15 years 0.5 - 5.9 ≤16
Adult 0.2 - 1.6 0.5 - 4.0

Plasma renin activity measures enzyme ability to convert angiotensinogen to angiotensin I and is limited by the availability of angiotensinogen. Plasma renin activity is not an accurate indicator of enzyme activity when angiotensinogen is decreased.
 

Age Aldosterone Posture Unspecified Supine Upright
0-6 days 5.0-102.0 ng/dL    
1-3 weeks 6.0-179.0 ng/dL    
1-11 months 7.0-99.0 ng/dL    
1-2 years 7.0-93.0 ng/dL    
3-10 years 4.0-44.0 ng/dL    
11-14 years 4.0-31.0 ng/dL    
15 years and older Less than or equal to 31.0 ng/dL Less than or equal to 16.0 ng/dL 4.0-31.0 ng/dL

 

Methodology

Method: Quantitative Chemiluminescent Immunoassay/Quantitative Enzyme-Linked Immunosorbent Assay

Analytical Volume: 0.5 mL Serum AND 1.2 mL Plasma

Limitations:

CPT Codes

82088, 84244

Send Out Instructions

Reference Test Name: Aldosterone/Renin Activity Ratio
Reference Test Number:

0070073

Instructions:

Send out Monday - Friday with the ARUP courier.