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HelpAldosterone/Renin Activity Ratio
Clinical System Name
Miscellaneous Test
Synonyms
Aldosterone
Aldosterone and Plasma Renin Activity
Aldosterone serum
Aldosterone/Renin Activity
ARR
ARR-P
PRA
Renin Activity
Sample Requirements
Specimen: Whole Blood
Container(s): Gold SST or Red
Preferred Vol: 2.0 mL
Minimum Vol: 1.0 mL
AND
Specimen: Whole Blood
Container(s): Lavender/EDTA
Preferred Vol: 4 mL
Minimum Vol: 2.4 mL
Note:
SUPINE: Obtain sample 0800-1000 AM, fasting starting at midnight, on a normal sodium diet (100-200 mEq/day).
UPRIGHT: Samples obtained before noon (after at least 2 hours in upright position), on a normal sodium diet.
Processing Instructions
Reject due to: Plasma collected in citrate, heparin, or oxalate. Hemolyzed specimens.
Spin: Y
Aliquot: Y
Temp: -20 C
Storage location: CPA -20 freezer, Send Outs rack. CRITICAL FROZEN. Spun plasma must be frozen within one hour.
Off-site collection: CRITICAL FROZEN. Spun plasma must be frozen within one hour. Spin blood, aliquot plasma and send frozen. If ordered with other tests, must be received in an individual aliquot container frozen.
Stability
| Specimen Type | Temperature | Time |
| Plasma | Room Temp | 6 h |
| Refrigerated | Unacceptable | |
| Frozen | 1 m | |
| Serum | Room Temp | 8 h |
| Refrigerated | 5 d | |
| Frozen | 1 m |
Availability
| STAT | Performed | TAT |
|---|---|---|
| N | Daily | 1 - 5 d |
Performing Laboratory
ARUP Laboratories
500 Chipeta Way
Salt Lake City, UT 84108-1221
Phone Number: (800) 522-2787
Department
Department: Send Outs
Phone Number: (206) 987-2563
CPT Codes
82088, 84244
Methodology
Method: Quantitative Chemiluminescent Immunoassay/Quantitative Enzyme-Linked Immunosorbent Assay
Analytical Volume: 0.5 mL Serum AND 1.2 mL Plasma
Limitations:
Reference Range
| Age | Renin Supine (ng/mL/hr) | Upright (ng/mL/hr) |
| Newborn (1 - 7 days) | 2.0 - 35.0 | NA |
| Cord Blood | 4.0 - 32.0 | NA |
| 1 - 12 months | 2.4 - 37.0 | NA |
| 13 months - 3 years | 1.7 - 11.2 | NA |
| 4 - 5 years | 1.0 - 6.5 | ≤15 |
| 6 - 10 years | 0.5 - 5.59 | ≤17 |
| 11 - 15 years | 0.5 - 5.9 | ≤16 |
| Adult | 0.2 - 1.6 | 0.5 - 4.0 |
Plasma renin activity measures enzyme ability to convert
angiotensinogen to angiotensin I and is limited by the availability
of angiotensinogen. Plasma renin activity is not an accurate
indicator of enzyme activity when angiotensinogen is decreased.
| Age | Aldosterone Posture Unspecified | Supine | Upright |
|---|---|---|---|
| 0-6 days | 5.0-102.0 ng/dL | ||
| 1-3 weeks | 6.0-179.0 ng/dL | ||
| 1-11 months | 7.0-99.0 ng/dL | ||
| 1-2 years | 7.0-93.0 ng/dL | ||
| 3-10 years | 4.0-44.0 ng/dL | ||
| 11-14 years | 4.0-31.0 ng/dL | ||
| 15 years and older | Less than or equal to 31.0 ng/dL | Less than or equal to 16.0 ng/dL | 4.0-31.0 ng/dL |
Send Out Instructions
| Reference Test Name: | Aldosterone/Renin Activity Ratio |
| Reference Test Number: |
0070073 |
| Instructions: |
Send out Monday - Friday with the ARUP courier. |