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Heme Gene Panel by NGS

Important Note

This test is under Utilization Management. All requests are reviewed and must be approved by a pathologist as part of the lab stewardship program.

Clinical System Name

Miscellaneous Genetic Test


This assay is a multiplexed gene sequencing panel designed to detect mutations associated with hematologic myeloid and lymphoid disorders. Purified genomic DNA is enzymatically sheared and targeted sequences are isolated by hybrid capture probes and sequenced by using an Illumina NGS platform.


This assay will not detect variants if present in only a small proportion of cells in the sample. If indicated, additional testing for FLT3-ITD and CEBPA mutations for new evaluation of acute myeloid leukemia should be separately ordered.


This assay is not intended for post-treatment disease monitoring nor comprehensive germline evaluation and is not validated to detect all classes of genomic alterations, such as large structural events including fusions and copy alterations.


Single gene testing can also be ordered as a MISC genetic test.


Sample Requirements

Specimen: Bone Marrow

Container(s): Lavender/EDTA

Preferred Vol: 2.0 mL

Minimum Vol: 1.0 mL


Specimen: Blood

Container(s): Lavender/EDTA

Preferred Vol: 6.0 mL


Processing Instructions

Reject due to:

Spin: N

Aliquot: N

Temp: RT or 2 - 4 C (see Storage Location instructions)

Storage Location: During business hours, call Send Outs for special handling. If received after hours or on weekends, place sample in the CPA 1 refrigerator's Send Outs rack.

Optimal results are achieved when samples are received within 48 hours of collection for bone marrow and peripheral blood.


Specimen Type Temperature Time
Bone Marrow Room temp 3 d
  Refrigerated 7 d



STAT Performed TAT
N Weekly 10 - 12 d


Performing Laboratory

UW / Seattle Cancer Care Alliance

Hematopathology Laboratory

825 Eastlake Avenue E., G7-800

Seattle, WA 98109


Phone Number: (206) 288-7060

Intake Hours: Monday - Friday 08:00 - 18:30 PST


Department: Send Outs

Phone Number: (206) 987-2563

Reference Ranges

Interpretive report provided.


Method: Amplification of the stated genetic regions followed by sequencing using an Illumina instrument

Analytical Volume: 1.0 mL Bone Marrow


Send Out Instructions

Reference Test Name:

Heme Gene Panel by NGS

Reference Test Code: HCAPA
Instructions: During business hours, call Send Outs for special handling. If received after hours or on weekends, place sample in the CPA 3 refrigerator's Send Outs rack. Send Monday through Friday via Delivery Express.