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Test Code ANGIO CONV Angiotensin Converting Enzyme, Serum

Reporting Name

Angiotensin Converting Enzyme, S

Useful For

Evaluation of patients with suspected sarcoidosis

Specimen Required

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Additional Information: The use of angiotensin converting enzyme (ACE)-inhibiting antihypertensive drugs will cause decreased ACE values.

Seattle Children's Hospital Note:

Collect 2.0 mL whole blood in Red top.

Specimen Type


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 7 days
  Frozen  180 days

Day(s) and Time(s) Performed

Monday through Saturday; Continuously

Performing Laboratory

Mayo Medical Laboratories in Rochester

Method Name

Spectrophotometry (SP)

Method Description

The method for quantitative serum angiotensin converting enzyme is based on the spectrophotometric quantitation of N-(3-[2-furyl]acryloyl)-L-phenylalanylglycylglycine to furylacylolphenylalanine and glycylglycine with concomitant decrease in absorbance at 340 nm.(Maguire GA, Price CP: A continuous monitoring spectrophotometric method for the measurement of angiotensin-converting enzyme in human serum. Ann Clin Biochem 1985;22:204-210)

Reference Values

≥18 years: 8-53 U/L

The reference interval for pediatric patients may be up to 50% higher than that of adults.


For SI unit Reference Values, see

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
ACE Angiotensin Converting Enzyme, S 2742-5


Result ID Test Result Name Result LOINC Value
ACE Angiotensin Converting Enzyme, S 2742-5

Reject Due To


Mild reject; Gross reject


Mild OK; Gross reject


Mild reject; Gross reject




If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

General Request Form (T239) (

Cardiovascular Test Request Form (T724) (