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Test Code Al Raspbrry Raspberry, IgE, Serum

Reporting Name

Raspberry, IgE

Useful For

Establishing the diagnosis of an allergy to raspberry

 

Defining the allergen responsible for eliciting signs and symptoms 

 

Identifying allergens:

- Responsible for allergic disease and/or anaphylactic episode

- To confirm sensitization prior to beginning immunotherapy

- To investigate the specificity of allergic reactions to insect venom allergens, drugs, or chemical allergens

 

Testing for IgE antibodies is not useful in patients previously treated with immunotherapy to determine if residual clinical sensitivity exists, or in patients in whom the medical management does not depend upon identification of allergen specificity.


Ordering Guidance


Designate specific allergens from the list in Allergens - Immunoglobulin E (IgE) Antibodies in Special Instructions.



Specimen Required


Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 0.5 mL for every 5 allergens requested


Specimen Type

Serum

Specimen Minimum Volume

For 1 allergen: 0.3 mL
For more than 1 allergen: (0.05 mL x number of allergens) + 0.25 mL dead space

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  90 days

Day(s) Performed

Monday through Friday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Method Name

Fluorescence Enzyme Immunoassay (FEIA)

Method Description

Specific IgE from the patient's serum reacts with the allergen of interest, which is covalently coupled to an ImmunoCAP. After washing away nonspecific IgE, enzyme-labeled anti-IgE antibody is added to form a complex. After incubation, unbound anti-IgE is washed away, and the bound complex is then incubated with a developing agent. After stopping the reaction, the fluorescence of the eluate is measured. Fluorescence is proportional to the amount of specific IgE present in the patient's sample (ie, the higher the fluorescence value, the more IgE antibody is present).(Package insert: ImmunoCAP System Specific IgE FEIA. Phadia; Rev 06/2019)

Reference Values

Class

IgE kU/L

Interpretation

0

<0.35

Negative

1

0.35-0.69

Equivocal

2

0.70-3.49

Positive

3

3.50-17.4

Positive

4

17.5-49.9

Strongly positive

5

50.0-99.9

Strongly positive

6

≥100

Strongly positive

Reference values apply to all ages.

Test Classification

This test was developed using an analyte specific reagent. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86003

LOINC Code Information

Test ID Test Order Name Order LOINC Value
RASP Raspberry, IgE 7656-2

 

Result ID Test Result Name Result LOINC Value
RASP Raspberry, IgE 7656-2

Report Available

1 to 3 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK