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Test Code C5 C5 Complement, Antigen, Serum

Reporting Name

C5 Complement, Antigen, S

Useful For

Diagnosis of C5 deficiency

 

Investigation of a patient with an absent total complement (CH50) level


Advisory Information


The total complement assay (COM / Complement, Total, Serum) should be used as a screen for suspected complement deficiencies before ordering individual complement component assays. A deficiency of an individual component of the complement cascade will result in an undetectable total complement level.



Specimen Required


Patient Preparation: Fasting preferred but not required

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and separate serum from clot.


Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Frozen (preferred) 60 days
  Refrigerated  28 days
  Ambient  7 days

Day(s) and Time(s) Performed

Monday, Wednesday, Friday

Seattle Children's Hospital Note:

TAT: 3 - 5 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Method Name

Nephelometry

Method Description

C5 complement antigen is measured by immunonephelometry. Antiserum to C5 is mixed with patient serum, the light scatter resulting from the antibody interaction with C5 is measured, and the signal is compared to standard concentrations of C5.(Unpublished Mayo information; Instruction manual: Siemens Nephelometer II l Version 3, Siemens, Inc., Newark, DE, 2008)

Reference Values

10.6-26.3 mg/dL

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

86160

LOINC Code Information

Test ID Test Order Name Order LOINC Value
C5AG C5 Complement, Antigen, S 4505-4

 

Result ID Test Result Name Result LOINC Value
C5AG C5 Complement, Antigen, S 4505-4

Reject Due To

Hemolysis

Mild OK; Gross OK

Lipemia

Mild OK; Gross reject

Icterus

Mild OK; Gross OK

Other

NA