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HelpTest Code C7 C7 Complement, Functional, Serum
Reporting Name
C7 Complement, Functional, SUseful For
Diagnosis of C7 deficiency
Investigation of a patient with an undetectable total complement level
Ordering Guidance
The total complement assay (COM / Complement, Total, Serum) assay should be used as a screen for suspected complement deficiencies before ordering individual complement component assays. A deficiency of an individual component of the complement cascade will result in an undetectable total complement level.
Specimen Required
Patient Preparation: Fasting preferred
Supplies: Sarstedt 5 mL Aliquot Tube (T914)
Collection Container/Tube: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Immediately after specimen collection, place the tube on wet ice.
2. Centrifuge and aliquot serum into plastic vial.
3. Immediately freeze specimen.
Specimen Type
Serum RedSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Frozen | 14 days |
Day(s) Performed
Monday through FridayTAT: 3 - 5 days
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Method Name
Automated Liposome Lysis Assay
Method Description
C7 complement activity is measured by mixing patient serum with a C7-deficient serum. The lytic activity of the serum mixture is tested against sensitized, labeled liposomes. If lysis occurs, the patient serum must be the source of the C7. The target liposomes are a commercial reagent (WAKO total complement CH50), and the assay is performed on an Advia XPT.(Unpublished Mayo method)
Reference Values
36-60 U/mL
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
86161
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| C7FX | C7 Complement, Functional, S | 87724-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| C7FX | C7 Complement, Functional, S | 87724-1 |
Report Available
1 to 3 daysReject Due To
| Gross hemolysis | OK |
| Gross lipemia | Reject |
| Gross icterus | OK |