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Test Code CALCITONIN Calcitonin, Serum

Reporting Name

Calcitonin, S

Useful For

Aids in the diagnosis and follow-up of medullary thyroid carcinoma

 

Aids in the evaluation of multiple endocrine neoplasia type II and familial medullary thyroid carcinoma


Specimen Required


Patient Preparation: 12 hours before this blood test do not take multivitamins or dietary supplements containing biotin or vitamin B7, which are commonly found in hair, skin, and nail supplements and multivitamins.

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.8 mL

Collection Instructions:

1. After draw immediately place specimen on ice.

2. Refrigerate specimen during centrifugation and immediately transfer serum to a plastic vial.


Seattle Children's Hospital Note:

Collect 1.6 mL whole blood in Red top.

Specimen Type

Serum

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Frozen (preferred) 90 days
  Refrigerated  24 hours
  Ambient  4 hours

Day(s) and Time(s) Performed

Monday through Friday; 5 a.m.-12 a.m.

Saturday; 6 a.m.-6 p.m.

Seattle Children's Hospital Note:

TAT: 3 - 5 days

Performing Laboratory

Mayo Medical Laboratories in Rochester

Method Name

Electrochemiluminescence Immunoassay

Method Description

Testing is performed on the Roche Cobas e601. The Roche Human Calcitonin (hCT) assay is a sandwich electrochemiluminescence immunoassay that employs a biotinylated monoclonal hCT-specific antibody and a monoclonal hCT-specific antibody. Calcitonin in the specimen reacts with both the biotinylated monoclonal hCT-specific antibody and the monoclonal hCT-specific antibody labeled with a ruthenium complex, forming a sandwich complex. Streptavidin-coated microparticles are added and the mixture is aspirated into the measuring cell where the microparticles are magnetically captured onto the surface of the electrode. Unbound substances are then removed with ProCell. Application of voltage to the electrode induces the chemiluminescent emission, which is then measured.(Package insert: Roche Calcitonin, Roche Diagnostics, 2014-03, v1)

Reference Values

Pediatric

1 month: ≤34 pg/mL

2 months: ≤31 pg/mL

3 months: ≤28 pg/mL

4 months: ≤26 pg/mL

5 months: ≤24 pg/mL

6 months: ≤22 pg/mL

7 months: ≤20 pg/mL

8 months: ≤19.0 pg/mL

9 months: ≤17.0 pg/mL

10 months: ≤16.0 pg/mL

11 months: ≤15.0 pg/mL

12-14 months: ≤14.0 pg/mL

15-17 months: ≤12.0 pg/mL

18-20 months: ≤10.0 pg/mL

21-23 months: ≤9.0 pg/mL

2 years: ≤8.0 pg/mL

3-9 years: ≤7.0 pg/mL

10-15 years: ≤6.0 pg/mL

16 years: ≤5.0 pg/mL

 

Adults

17 years and older:

Males: ≤14.3 pg/mL

Females: ≤7.6 pg/mL

 

For SI unit Reference Values, see https://www.mayomedicallaboratories.com/order-tests/si-unit-conversion.html.

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82308

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CATN Calcitonin, S 1992-7

 

Result ID Test Result Name Result LOINC Value
CATN Calcitonin, S 1992-7

Reject Due To

Hemolysis

Mild OK; Gross reject

Lipemia

Mild OK; Gross OK

Icterus

NA

Other

NA