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Test Code HepE IgG Hepatitis E Virus IgG Antibody, Serum

Reporting Name


Useful For

Diagnosis of past exposure to hepatitis E virus

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Serum SST

Specimen Required

Collection Container/Tube: Serum gel       

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Seattle Children's Hospital Note:

Collect 1.0 mL whole blood in a Red top.

Specimen Minimum Volume

0.1 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum SST Frozen (preferred)
  Refrigerated  24 hours

Reference Values


Day(s) and Time(s) Performed

Wednesday, Friday; Varies

Seattle Children's Hospital Note:

TAT: 8 - 10 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
HEVG HEV IgG Ab, S 49693-5


Result ID Test Result Name Result LOINC Value
86211 HEV IgG Ab, S 49693-5

Method Description

Highly purified recombinant hepatitis E virus (HEV)-ORF2 (from HEV genotypes 1 and 3) viral antigens are fixed to microplate wells. Diluted patient serum specimen is incubated in the well, in which antibodies bind specifically to the HEV recombinant antigens coating the surface of the well. Unbound human antibodies are then washed away, followed by addition of antihuman IgG antibodies that are conjugated to horseradish peroxidase enzyme for incubation. Unbound conjugate antibodies are then washed away, and a chromogenic substrate is added to the well. Human anti-HEV IgG antibodies specifically bound to the HEV antigens in the wells are detected by the peroxidase-catalyzed color reaction. Intensity of the color as measured with a photometric analyzer is proportionate to the quantity of bound HEV IgG antibodies present in the serum specimen.(Package insert: recomWell HEV IgG/IgM kit, catalog no. 5004/5005, Mikrogen GmbH, Foster, Neuried, Germany, rev.3/2016)

Reject Due To


Mild OK; Gross Reject


Mild OK; Gross Reject


Mild OK; Gross Reject



Method Name

Enzyme Immunoassay (EIA)-Screening Procedure

Testing Algorithm

See Testing Algorithm for the Diagnosis of Hepatitis E in Special Instructions.